Drug General Information (ID: DDIO9DVZLG)
Drug Name			Aluminum hydroxide		Drug Info		Riociguat		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antacids				Vasodilator Agents
Structure

Mechanism of Aluminum hydroxide-Riociguat Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Aluminum hydroxide				Riociguat
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Riociguat due to altered gastric pH caused by Aluminum hydroxide

Recommended Action
Management		Antacids should not be taken within 1 hour of riociguat administration.

References
1	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.