Drug General Information (ID: DDINQ9ZHJI)
Drug Name			Riociguat		Drug Info		Isoxsuprine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasodilator Agents				Peripheral Vasodilators
Structure

Mechanism of Riociguat-Isoxsuprine Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Riociguat				Isoxsuprine
Mechanism 1		Hypotensive effects Soluble guanylyl cyclase  Agonist				Antihypertensive agent
Key Mechanism Factor 1
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Riociguat and Isoxsuprine
Mechanism 2		Hypotensive effects Soluble guanylyl cyclase  Agonist				Hypotensive effects
Key Mechanism Factor 2
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Riociguat and Isoxsuprine

Recommended Action
Management		Caution is advised if riociguat is prescribed in combination with antihypertensive agents or other vasodilators.

References
1	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.