Details of Drug Interaction | MecDDI

Drug General Information (ID: DDI3SZ7O8R)
Drug Name			Triamterene		Drug Info		Riociguat		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Vasodilator Agents
Structure

Mechanism of Triamterene-Riociguat Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph

Drug Name		Triamterene				Riociguat
Mechanism		Antihypertensive agent Amiloride-sensitive sodium channel Blocker				Hypotensive effects Soluble guanylyl cyclase Agonist
Key Mechanism Factor 1
		Factor Name		Amiloride-sensitive sodium channel				Structure Sequence
		Protein Family		Amiloride-sensitive sodium channel (TC 1.A.6) family
		Protein Function		Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Click to Show/Hide
Key Mechanism Factor 2
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Triamterene and Riociguat

Recommended Action
Management		Caution is advised if riociguat is prescribed in combination with antihypertensive agents or other vasodilators.

References
1	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.