Drug General Information (ID: DDI10RJNAY)
Drug Name			Riociguat		Drug Info		Sodium citrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasodilator Agents				Minerals And Electrolytes
Structure

Mechanism of Riociguat-Sodium citrate Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Riociguat				Sodium citrate
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Riociguat due to altered gastric pH caused by Sodium citrate

Recommended Action
Management		Antacids should not be taken within 1 hour of riociguat administration.

References
1	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.