Drug General Information (ID: DDICT2O73Z)
Drug Name			Dexlansoprazole		Drug Info		Riociguat		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Proton Pump Inhibitors				Vasodilator Agents
Structure

Mechanism of Dexlansoprazole-Riociguat Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Dexlansoprazole				Riociguat
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Riociguat due to altered gastric pH caused by Dexlansoprazole

Recommended Action
Management		No dosage adjustment for riociguat is recommended when coadministered with proton pump inhibitors. However, patients should be monitored for potentially diminished therapeutic effects of riociguat.

References
1	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.