Drug General Information (ID: DDIRPE326C)
Drug Name			Papaverine		Drug Info		Riociguat		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasodilator Agents				Vasodilator Agents
Structure

Mechanism of Papaverine-Riociguat Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Papaverine				Riociguat
Mechanism		Hypotensive effects Phosphodiesterase 4D/5A  Inhibitor				Hypotensive effects Soluble guanylyl cyclase  Agonist
Key Mechanism Factor 1
		Factor Name		Phosphodiesterase				Structure Sequence
		Protein Family		Cyclic nucleotide phosphodiesterase family
		Protein Function		Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.     Click to Show/Hide
Key Mechanism Factor 2
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Papaverine and Riociguat

Recommended Action
Management		Caution is advised if riociguat is prescribed in combination with antihypertensive agents or other vasodilators.

References
1	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.