Details of Drug

Drug General Information (ID: D1223)
Drug Name	Papaverine
Drug Type	Small molecule
Drug Synonymous	papaverine; Papaverin; Papanerine; Robaxapap; 58-74-2; Papanerin; Pavabid; Papaverina; Pavatym; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline; Cerespan; Papaverine [BAN]; Pavacot; Papaverina [Italian]; 6,7-Dimethoxy-1-veratrylisoquinoline; Papaverine Hcl; NSC 136630; UNII-DAA13NKG2Q; Isoquinoline, 6,7-dimethoxy-1-veratryl-; S-M-R; Papaverine (BAN); Pamelon; Chlorhydrate de papaverine; Qua bid; 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-isoquinoline; 1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline; Alapav; Cardiospan; Cardoverina; Ceraspan; Cerebid; Delapav; Dilaves; Dispamil; Drapavel; Durapav; Dynovas; Forpavin; Genabid; Mesotina; Myobid; Pameion; Panergon; Papacon; Papalease; Papaversan; Pavacap; Pavacels; Pavacen; Pavagen; Pavarine; Pavatest; Pavatine; Paverolan; Paveron; Pavnell; Vasal; PAP H; Papavarine chlorhydrate; Papaverine chlorohydrate; Papaverine monohydrochloride; Papaverinium chloride; Pavabid Hp; RS 47; TNP00305; Alapav (TN); Albatran (TN); Artegodan (TN); Cardiospan (TN); Cardioverina (TN); Cepaverin (TN); Cerebid (TN); Cerespan (TN); Delapav (TN); Dicertan (TN); Dilaves (TN); Dispamil (TN); Drapavel (TN); Durapav (TN); Dynovas (TN); Forpaven (TN); Houde (TN); Mesotina (TN); Myobid (TN); Opdensit (TN); Optenyl (TN); Pameion (TN); Pamelon (TN); Panergon (TN); Papacon (TN); Papalease (TN); Papanerin-hcl; Papaversan (TN); Pavabid (TN); Pavacap (TN); Pavacen (TN); Pavadel (TN); Pavadyl (TN); Pavagen (TN); Pavakey (TN); Pavased (TN); Pavatest (TN); Paverina (TN); Paverolan (TN); Paveron (TN); Pavnell (TN); Qua bid (TN); Ro-Papav; Therapav (TN); Vasal (TN); Vaso-Pav; Vasospan (TN); Papanerin-hcl (TN); Papaverin-Hamelin (TN); Papital TR; Paptial TR; Ro-Papav (TN); Spasmo-Nit (TN); Vaso-Pav (TN); Pap-Kaps-150 (TN); Papital TR (TN); Paptial TR (TN); Isoquinoline,6,7-dimethoxy-1-veratryl-(8CI); Isoquinoline, 6,7-dimethoxy-1-veratryl-(8Cl); 1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline; 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline; 1-{[3,4-bis(methyloxy)phenyl]methyl}-6,7-bis(methyloxy)isoquinoline; 4-[(6,7-Dimethoxyisoquinolyl)methyl]-1,2-dimethoxybenzene; 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline; 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE Click to Show/Hide
Disease Class	MB47: Tonus and reflex abnormality
Therapeutic Class	Vasodilator Agents
Structure
Structure	3D Structure		2D Structure
Formula	C20H21NO4
InChI	1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
InChIKey	XQYZDYMELSJDRZ-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC
External Link
	Pubchem ID	4680
	CAS Number	58-74-2
	CHEBI ID	28241
	TTD ID	D0NJ3V
	INTEDE ID	DR2299
	VARIDT ID	DR00967

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM042 Additive hypotensive effects BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Papaverine
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 53
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[13]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[14], [15], [16]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[14], [15], [16]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[11], [28], [29]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[30], [31], [32]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1848		Minoxidil (topical)	C9H15N5O	4201	Moderate		Inter Info	[46], [47]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[48], [43], [49]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[50], [51], [52]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[11], [30], [53]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[11], [30], [53]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[11], [30], [53]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[30], [31], [32]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[57]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[58], [59], [60]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[61]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[62], [63], [64]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[65]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[30], [31], [32]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[66]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[50], [51], [52]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[30], [31], [32]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[50], [51], [52]
D0711		Garlic	NA	NA	Minor		Inter Info	[68], [69]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[70], [71]
	Increased risk of prolong QT interval					Drug Num: 165
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0003		Abarelix	C72H95ClN14O14	16131215	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[1], [3], [8]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[1], [3], [8]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[1], [3], [8]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0908		Leuprolide	C59H84N16O12	657181	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0947		Loperamide	C29H33ClN2O2	3955	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[1], [3], [8]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[1], [3], [8]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[1], [3], [8]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1], [3], [8]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0948		Lopinavir	C37H48N4O5	92727	Major		Inter Info	[1], [3], [8]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[1], [3], [8]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[9]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1342		Probucol	C31H48O2S2	4912	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1356		Propofol	C12H18O	4943	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1438		Salbutamol	C13H21NO3	2083	Major		Inter Info	[1], [3], [8]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
	Increased risk of ventricular arrhythmias					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[10]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[11], [12]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[54], [55], [56]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[67], [43]

References
1	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
2	Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
3	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
4	Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
5	Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
6	Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
7	Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
8	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
9	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
10	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
11	Cerner Multum, Inc. "Australian Product Information.".
12	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
13	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
14	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
15	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
16	Walters TR "Development and use of brimonidine in treating acute and chronic elevations of intraocular pressure: a review of safety, efficacy, dose response, and dosing studies." Surv Ophthalmol 41 ( Suppl (1996): s19-26
17	Aronowitz JS, Chakos MH, Safferman AZ, Lieberman JA "Syncope associated with the combination of clozapine and enalapril." J Clin Psychopharmacol 14 (1994): 429-30. [PMID: 7884028]
18	Fruncillo R, Gibbons W, Vlasses P, Ferguson R "Severe hypotension associated with concurrent clonidine and antipsychotic medication." Am J Psychiatry 142 (1985): 274. [PMID: 2857531]
19	Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9. [PMID: 7663034]
20	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
21	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
22	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
23	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
24	Product Information. Risperdal (risperidone). Janssen Pharmaceutica, Titusville, NJ.
25	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
26	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
27	White WB "Hypotension with postural syncope secondary to the combination of chlorpromazine and captopril." Arch Intern Med 146 (1986): 1833-4. [PMID: 3530167]
28	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
29	Product Information. Precedex (dexmedetomidine) Abbott Pharmaceutical, Abbott Park, IL.
30	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
31	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
32	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
33	Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
34	De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5. [PMID: 4379192]
35	Goldberg LI "Monoamine oxidase inhibitors: adverse reactions and possible mechanisms." JAMA 190 (1964): 456-62. [PMID: 14197995]
36	Golwyn DH, Sevlie CP "Monoamine oxidase inhibitor hypertensive crisis headache and orthostatic hypotension." J Clin Psychopharmacol 13 (1993): 77-8. [PMID: 8486823]
37	Kronig MH, Roose SP, Walsh BT, Woodring S, Glassman AH "Blood pressure effects of phenelzine." J Clin Psychopharmacol 3 (1983): 307-10. [PMID: 6630590]
38	Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7. [PMID: 5655478]
39	Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
40	Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
41	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
42	Product Information. Parnate (tranylcypromine). SmithKline Beecham, Philadelphia, PA.
43	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
44	Reggev A, Vollhardt BR "Bradycardia induced by an interaction between phenelzine and beta blockers." Psychosomatics 30 (1992): 106-8. [PMID: 2913594]
45	Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
46	Leenen FH, Smith DL, Unger WP "Topical minoxidil: cardiac effects in bald men." Br J Clin Pharmacol 26 (1988): 481-5. [PMID: 3191000]
47	Product Information. Rogaine (minoxidil topical). Johnson and Johnson/McNeil Consumer, Fort Washington, PA.
48	Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
49	Product Information. Ethyol (amifostine). Alza, Palo Alto, CA.
50	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
51	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
52	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
53	Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
54	Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR "Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age." Lancet 2 (1987): 821-4. [PMID: 2889032]
55	Cumming AM "Metabolic effects of licorice." Br Med J 1 (1977): 906
56	Epstein MT, Espiner EA, Donald RA, Hughes H "Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects." Br Med J 1 (1977): 488-90
57	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
58	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
59	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
60	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
61	Product Information. Natrecore (nesiritide) Scios Inc, Sunnyvale, CA.
62	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
63	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
64	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
65	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
66	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
67	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
68	Tattelman E "Health effects of garlic." Am Fam Physician 72 (2005): 103-6
69	Richard CL, Jurgens TM "Effects of natural health products on blood pressure." Ann Pharmacother 39 (2005): 712-20
70	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
71	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.

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