Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIJX3KIRA)
  Drug Name Tadalafil Drug Info Papaverine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Impotence Agents Vasodilator Agents
  Structure

 Mechanism of Tadalafil-Papaverine Interaction (Severity Level: Minor)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Tadalafil Papaverine
      Mechanism Hypotensive effects
Prostacyclin receptor  Agonist 		Hypotensive effects
Phosphodiesterase 4D/5A  Inhibitor
      Key Mechanism Factor 1
Factor Name Prostacyclin receptor
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Structure Sequence
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
Gene Name PTGIR
Uniprot ID PI2R_HUMAN
KEGG Pathway hsa:5739
Protein Family G-protein coupled receptor 1 family
Protein Function
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
    Click to Show/Hide
      Key Mechanism Factor 2
Factor Name Phosphodiesterase Structure Sequence
Protein Family Cyclic nucleotide phosphodiesterase family
Protein Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
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      Mechanism Description
  • Additive hypotensive effects by the combination of Tadalafil and Papaverine 

References
1 Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
2 Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.