Drug General Information (ID: DDIR7V08BY)
Drug Name			Papaverine		Drug Info		Garlic		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Vasodilator Agents				Herbal Products

Mechanism of Papaverine-Garlic Interaction (Severity Level: Minor)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Papaverine				Garlic
Mechanism 1		Hypotensive effects Phosphodiesterase 4D/5A  Inhibitor				Antihypertensive agent
Key Mechanism Factor 1
		Factor Name		Phosphodiesterase				Structure Sequence
		Protein Family		Cyclic nucleotide phosphodiesterase family
		Protein Function		Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Papaverine and Garlic
Mechanism 2		Hypotensive effects Phosphodiesterase 4D/5A  Inhibitor				Hypotensive effects
Key Mechanism Factor 2
		Factor Name		Phosphodiesterase				Structure Sequence
		Protein Family		Cyclic nucleotide phosphodiesterase family
		Protein Function		Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Papaverine and Garlic

References
1	Tattelman E "Health effects of garlic." Am Fam Physician 72 (2005): 103-6
2	Richard CL, Jurgens TM "Effects of natural health products on blood pressure." Ann Pharmacother 39 (2005): 712-20