Details of Drug

Drug General Information (ID: D0711)
Drug Name		Garlic
Drug Type		Natural product
Drug Synonymous		1-(prop-2-enyldisulfanyl)propane;3-prop-2-enylsulfinylsulfanylprop-1-ene;3-(prop-2-enyltrisulfanyl)prop-1-ene; 8000-78-0; Oils, garlic Click to Show/Hide
Therapeutic Class		Herbal Products

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM011 Transporter induction BM022 CYP450 enzyme induction BM042 Additive hypotensive effects BM050 Increased risk of bleeding BM064 Increased risk of hypoglycemia BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Garlic
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3], [4]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2], [3], [4]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1], [2], [3], [4]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2], [3], [4]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2], [3], [4]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2], [3], [4]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2], [3], [4]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[1], [2], [3], [4]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 103
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Minor		Inter Info	[24], [25]
D0012		Acetazolamide	C4H6N4O3S2	1986	Minor		Inter Info	[24], [25]
D0036		Alfuzosin	C19H27N5O4	2092	Minor		Inter Info	[24], [25]
D0038		Aliskiren	C30H53N3O6	5493444	Minor		Inter Info	[24], [25]
D0046		Alprostadil	C20H34O5	5280723	Minor		Inter Info	[24], [25]
D0058		Amiloride	C6H8ClN7O	16231	Minor		Inter Info	[24], [25]
D0069		Amlodipine	C20H25ClN2O5	2162	Minor		Inter Info	[24], [25]
D0083		Amyl Nitrite	C5H11NO2	10026	Minor		Inter Info	[24], [25]
D0117		Atenolol	C14H22N2O3	2249	Minor		Inter Info	[24], [25]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Minor		Inter Info	[24], [25]
D0156		Benazepril	C24H28N2O5	5362124	Minor		Inter Info	[24], [25]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Minor		Inter Info	[24], [25]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Minor		Inter Info	[24], [25]
D0170		Bepridil	C24H34N2O	2351	Minor		Inter Info	[24], [25]
D0173		Betaxolol	C18H29NO3	2369	Minor		Inter Info	[24], [25]
D0188		Bisoprolol	C18H31NO4	2405	Minor		Inter Info	[24], [25]
D0217		Bumetanide	C17H20N2O5S	2471	Minor		Inter Info	[24], [25]
D0254		Captopril	C9H15NO3S	44093	Minor		Inter Info	[24], [25]
D0265		Carteolol	C16H24N2O3	2583	Minor		Inter Info	[24], [25]
D0267		Carvedilol	C24H26N2O4	2585	Minor		Inter Info	[24], [25]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Minor		Inter Info	[24], [25]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Minor		Inter Info	[24], [25]
D0352		Clevidipine	C21H23Cl2NO6	153994	Minor		Inter Info	[24], [25]
D0363		Clonidine	C9H9Cl2N3	2803	Minor		Inter Info	[24], [25]
D0396		Cyclandelate	C17H24O3	2893	Minor		Inter Info	[24], [25]
D0444		Deserpidine	C32H38N2O8	8550	Minor		Inter Info	[24], [25]
D0474		Diazoxide	C8H7ClN2O2S	3019	Minor		Inter Info	[24], [25]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Minor		Inter Info	[24], [25]
D0497		Diltiazem	C22H26N2O4S	39186	Minor		Inter Info	[24], [25]
D0524		Doxazosin	C23H25N5O5	3157	Minor		Inter Info	[24], [25]
D0567		Enalapril	C20H28N2O5	5388962	Minor		Inter Info	[24], [25]
D0585		Eplerenone	C24H30O6	443872	Minor		Inter Info	[24], [25]
D0587		Eprosartan	C23H24N2O4S	5281037	Minor		Inter Info	[24], [25]
D0602		Esmolol	C16H25NO4	59768	Minor		Inter Info	[24], [25]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Minor		Inter Info	[24], [25]
D0640		Felodipine	C18H19Cl2NO4	3333	Minor		Inter Info	[24], [25]
D0644		Fenoldopam	C16H16ClNO3	3341	Minor		Inter Info	[24], [25]
D0695		Fosinopril	C30H46NO7P	55891	Minor		Inter Info	[24], [25]
D0704		Furosemide	C12H11ClN2O5S	3440	Minor		Inter Info	[24], [25]
D0742		Guanabenz	C8H8Cl2N4	5702063	Minor		Inter Info	[24], [25]
D0743		Guanadrel	C10H19N3O2	38521	Minor		Inter Info	[24], [25]
D0744		Guanethidine	C10H22N4	3518	Minor		Inter Info	[24], [25]
D0745		Guanfacine	C9H9Cl2N3O	3519	Minor		Inter Info	[24], [25]
D0770		Hydralazine	C8H8N4	3637	Minor		Inter Info	[24], [25]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Minor		Inter Info	[24], [25]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Minor		Inter Info	[24], [25]
D0798		Indapamide	C16H16ClN3O3S	3702	Minor		Inter Info	[24], [25]
D0844		Irbesartan	C25H28N6O	3749	Minor		Inter Info	[24], [25]
D0860		Isosorbide	C6H10O4	12597	Minor		Inter Info	[24], [25]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Minor		Inter Info	[24], [25]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Minor		Inter Info	[24], [25]
D0864		Isoxsuprine	C18H23NO3	3783	Minor		Inter Info	[24], [25]
D0865		Isradipine	C19H21N3O5	3784	Minor		Inter Info	[24], [25]
D0884		Labetalol	C19H24N2O3	3869	Minor		Inter Info	[24], [25]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Minor		Inter Info	[24], [25]
D0938		Lisinopril	C21H31N3O5	5362119	Minor		Inter Info	[24], [25]
D0954		Losartan	C22H23ClN6O	3961	Minor		Inter Info	[24], [25]
D0978		Mannitol	C6H14O6	6251	Minor		Inter Info	[24], [25]
D0983		Mecamylamine	C11H21N	4032	Minor		Inter Info	[24], [25]
D1018		Methazolamide	C5H8N4O3S2	4100	Minor		Inter Info	[24], [25]
D1035		Methyldopa	C10H13NO4	38853	Minor		Inter Info	[24], [25]
D1048		Metolazone	C16H16ClN3O3S	4170	Minor		Inter Info	[24], [25]
D1049		Metoprolol	C15H25NO3	4171	Minor		Inter Info	[24], [25]
D1053		Metyrosine	C10H13NO3	441350	Minor		Inter Info	[24], [25]
D1072		Minoxidil	C9H15N5O	4201	Minor		Inter Info	[24], [25]
D1082		Moexipril	C27H34N2O7	91270	Minor		Inter Info	[24], [25]
D1098		Nadolol	C17H27NO4	39147	Minor		Inter Info	[24], [25]
D1114		Nebivolol	C22H25F2NO4	71301	Minor		Inter Info	[24], [25]
D1125		Nesiritide	C143H244N50O42S4	53325981	Minor		Inter Info	[24], [25]
D1130		Nicardipine	C26H29N3O6	4474	Minor		Inter Info	[24], [25]
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[24], [25]
D1138		Nimodipine	C21H26N2O7	4497	Minor		Inter Info	[24], [25]
D1141		Nisoldipine	C20H24N2O6	4499	Minor		Inter Info	[24], [25]
D1146		Nitroglycerin	C3H5N3O9	4510	Minor		Inter Info	[24], [25]
D1147		Nitroprusside	C5FeN6O	11953891	Minor		Inter Info	[24], [25]
D1170		Olmesartan	C24H26N6O3	158781	Minor		Inter Info	[24], [25]
D1223		Papaverine	C20H21NO4	4680	Minor		Inter Info	[24], [25]
D1244		Penbutolol	C18H29NO2	37464	Minor		Inter Info	[24], [25]
D1256		Perindopril	C19H32N2O5	107807	Minor		Inter Info	[24], [25]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Minor		Inter Info	[24], [25]
D1271		Phentolamine	C17H19N3O	5775	Minor		Inter Info	[24], [25]
D1293		Pindolol	C14H20N2O2	4828	Minor		Inter Info	[24], [25]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Minor		Inter Info	[24], [25]
D1331		Prazosin	C19H21N5O4	4893	Minor		Inter Info	[24], [25]
D1357		Propranolol	C16H21NO2	4946	Minor		Inter Info	[24], [25]
D1369		Quinapril	C25H30N2O5	54892	Minor		Inter Info	[24], [25]
D1379		Ramipril	C23H32N2O5	5362129	Minor		Inter Info	[24], [25]
D1393		Reserpine	C33H40N2O9	5770	Minor		Inter Info	[24], [25]
D1498		Sotalol	C12H20N2O3S	5253	Minor		Inter Info	[24], [25]
D1501		Spironolactone	C24H32O4S	5833	Minor		Inter Info	[24], [25]
D1534		Tamsulosin	C20H28N2O5S	129211	Minor		Inter Info	[24], [25]
D1545		Telmisartan	C33H30N4O2	65999	Minor		Inter Info	[24], [25]
D1552		Terazosin	C19H25N5O4	5401	Minor		Inter Info	[24], [25]
D1585		Timolol	C13H24N4O3S	33624	Minor		Inter Info	[24], [25]
D1602		Tolazoline	C10H12N2	5504	Minor		Inter Info	[24], [25]
D1611		Torasemide	C16H20N4O3S	41781	Minor		Inter Info	[24], [25]
D1618		Trandolapril	C24H34N2O5	5484727	Minor		Inter Info	[24], [25]
D1631		Triamterene	C12H11N7	5546	Minor		Inter Info	[24], [25]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Minor		Inter Info	[24], [25]
D1643		Trimethaphan	C22H25N2OS+	23576	Minor		Inter Info	[24], [25]
D1668		Urea	CH4N2O	1176	Minor		Inter Info	[24], [25]
D1679		Valsartan	C24H29N5O3	60846	Minor		Inter Info	[24], [25]
D1690		Verapamil	C27H38N2O4	2520	Minor		Inter Info	[24], [25]
	Increased risk of bleeding					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[5], [13], [16]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0102		Ardeparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0415		Danaparoid	NA	NA	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[5], [13], [16]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[5], [13], [16]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[5], [13], [16]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
	Increased risk of hypoglycemia					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Minor		Inter Info	[11], [22], [23]
D0013		Acetohexamide	C15H20N2O4S	1989	Minor		Inter Info	[11], [22], [23]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Minor		Inter Info	[11], [22], [23]
D0727		Glimepiride	C24H34N4O5S	3476	Minor		Inter Info	[11], [22], [23]
D0728		Glipizide	C21H27N5O4S	3478	Minor		Inter Info	[11], [22], [23]
D0730		Glyburide	C23H28ClN3O5S	3488	Minor		Inter Info	[11], [22], [23]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Minor		Inter Info	[11], [22], [23]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Minor		Inter Info	[11], [22], [23]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Minor		Inter Info	[11], [22], [23]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Minor		Inter Info	[11], [22], [23]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Minor		Inter Info	[11], [22], [23]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Minor		Inter Info	[11], [22], [23]
D0813		Insulin human	C257H383N65O77S6	118984375	Minor		Inter Info	[11], [22], [23]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Minor		Inter Info	[11], [22], [23]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Minor		Inter Info	[11], [22], [23]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Minor		Inter Info	[11], [22], [23]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Minor		Inter Info	[11], [22], [23]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Minor		Inter Info	[11], [22], [23]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Minor		Inter Info	[11], [22], [23]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Minor		Inter Info	[11], [22], [23]
D1015		Metformin	C4H11N5	4091	Minor		Inter Info	[11], [22], [23]
D1064		Miglitol	C8H17NO5	441314	Minor		Inter Info	[11], [22], [23]
D1112		Nateglinide	C19H27NO3	5311309	Minor		Inter Info	[11], [22], [23]
D1294		Pioglitazone	C19H20N2O3S	4829	Minor		Inter Info	[11], [22], [23]
D1392		Repaglinide	C27H36N2O4	65981	Minor		Inter Info	[11], [22], [23]
D1429		Rosiglitazone	C18H19N3O3S	77999	Minor		Inter Info	[11], [22], [23]
D1601		Tolazamide	C14H21N3O3S	5503	Minor		Inter Info	[11], [22], [23]
D1603		Tolbutamide	C12H18N2O3S	5505	Minor		Inter Info	[11], [22], [23]
D1652		Troglitazone	C24H27NO5S	5591	Minor		Inter Info	[11], [22], [23]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[20], [21]

References
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20	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
21	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
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24	Tattelman E "Health effects of garlic." Am Fam Physician 72 (2005): 103-6
25	Richard CL, Jurgens TM "Effects of natural health products on blood pressure." Ann Pharmacother 39 (2005): 712-20

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