Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIQ6IYCWN)
  Drug Name Valsartan Drug Info Garlic Drug Info
  Drug Type Small molecule Natural product
  Therapeutic Class Antihypertensive Agents Herbal Products

 Mechanism of Valsartan-Garlic Interaction (Severity Level: Minor)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Valsartan Garlic
      Mechanism 1 Antihypertensive agent
Amiloride-sensitive sodium channel  Blocker 		Antihypertensive agent
      Key Mechanism Factor 1
Factor Name Amiloride-sensitive sodium channel Structure Sequence
Protein Family Amiloride-sensitive sodium channel (TC 1.A.6) family
Protein Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Valsartan and Garlic 
      Mechanism 2 Antihypertensive agent
Amiloride-sensitive sodium channel  Blocker 		Hypotensive effects
      Key Mechanism Factor 2
Factor Name Amiloride-sensitive sodium channel Structure Sequence
Protein Family Amiloride-sensitive sodium channel (TC 1.A.6) family
Protein Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Valsartan and Garlic 

References
1 Tattelman E "Health effects of garlic." Am Fam Physician 72 (2005): 103-6
2 Richard CL, Jurgens TM "Effects of natural health products on blood pressure." Ann Pharmacother 39 (2005): 712-20