Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIY083KLE)
  Drug Name Olmesartan Drug Info Garlic Drug Info
  Drug Type Small molecule Natural product
  Therapeutic Class Antihypertensive Agents Herbal Products

 Mechanism of Olmesartan-Garlic Interaction (Severity Level: Minor)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Olmesartan Garlic
      Mechanism 1 Antihypertensive agent
Angiotensin II receptor  Antagonist 		Antihypertensive agent
      Key Mechanism Factor 1
Factor Name Angiotensin II receptor Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Olmesartan and Garlic 
      Mechanism 2 Antihypertensive agent
Angiotensin II receptor  Antagonist 		Hypotensive effects
      Key Mechanism Factor 2
Factor Name Angiotensin II receptor Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Olmesartan and Garlic 

References
1 Tattelman E "Health effects of garlic." Am Fam Physician 72 (2005): 103-6
2 Richard CL, Jurgens TM "Effects of natural health products on blood pressure." Ann Pharmacother 39 (2005): 712-20