Drug General Information (ID: DDI0CTMIVF)
Drug Name			Isosorbide		Drug Info		Garlic		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antianginal Agents				Herbal Products

Mechanism of Isosorbide-Garlic Interaction (Severity Level: Minor)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Isosorbide				Garlic
Mechanism 1		Antihypertensive agent Guanylate cyclase  Agonist				Antihypertensive agent
Key Mechanism Factor 1
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Isosorbide and Garlic
Mechanism 2		Antihypertensive agent Guanylate cyclase  Agonist				Hypotensive effects
Key Mechanism Factor 2
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Isosorbide and Garlic

References
1	Tattelman E "Health effects of garlic." Am Fam Physician 72 (2005): 103-6
2	Richard CL, Jurgens TM "Effects of natural health products on blood pressure." Ann Pharmacother 39 (2005): 712-20