Details of Drug

Details of Drug

 Drug General Information (ID: D0860)
  Drug Name
Isosorbide
  Drug Type Small molecule
  Drug Synonymous
AT-101, Atumida; Hyperpermeability inhibitor (hemorrhagic shock), Atumida
    Click to Show/Hide
  Disease Class MG40: Shock
  Therapeutic Class Antianginal Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C6H10O4
  InChI 1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1
  InChIKey KLDXJTOLSGUMSJ-JGWLITMVSA-N
  Canonical SMILES C1C(C2C(O1)C(CO2)O)O
  External Link
Pubchem ID 12597
CAS Number 652-67-5
CHEBI ID 6060
TTD ID D0S6KI

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM042  Additive hypotensive effects
BM071  Increased risk of methemoglobinemia
BM072  Increased risk of nephrotoxicity
BM089  Antagonize the effect of antihypertensive agents
BM107  Attenuated pharmacological effects (Unspecific)
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Isosorbide
      Pharmacodynamic additive effects
   Additive hypotensive effects Drug Num:  58
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0128
 
Avanafil
 
C23H26ClN7O3
 
9869929 
Major    Inter Info   
[1], [2], [3]
D1408
 
Riociguat
 
C20H19FN8O2
 
11304743 
Major    Inter Info   
[10]
D1465
 
Sildenafil
 
C22H30N6O4S
 
135398744 
Major    Inter Info   
[1], [2], [3]
D1527
 
Tadalafil
 
C22H19N3O4
 
110635 
Major    Inter Info   
[1], [2], [3]
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Major    Inter Info   
[11]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Major    Inter Info   
[1], [2], [3]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[12], [13], [14]
D0055
 
Amifostine
 
C5H15N2O3PS
 
2141 
Moderate    Inter Info   
[15], [16], [17]
D0067
 
Amisulpride
 
C17H27N3O4S
 
2159 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0098
 
Apraclonidine
 
C9H10Cl2N4
 
2216 
Moderate    Inter Info   
[26], [27], [28]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0202
 
Brexpiprazole
 
C25H27N3O2S
 
11978813 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0205
 
Brimonidine (ophthalmic)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[26], [27], [28]
D0206
 
Brimonidine (topical)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[26], [27], [28]
D0262
 
Cariprazine
 
C21H32Cl2N4O
 
11154555 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0586
 
Epoprostenol
 
C20H32O5
 
5282411 
Moderate    Inter Info   
[29], [32], [33]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0792
 
Iloprost
 
C22H32O4
 
5311181 
Moderate    Inter Info   
[29], [32], [33]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Moderate    Inter Info   
[34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [16], [44], [45]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [16], [44], [45]
D1457
 
Selexipag
 
C26H32N4O4S
 
9913767 
Moderate    Inter Info   
[29], [32], [33]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Moderate    Inter Info   
[34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [16], [44], [45]
D0957
 
Loxapine
 
C18H18ClN3O
 
3964 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0959
 
Lumateperone
 
C24H28FN3O
 
21302490 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0961
 
Lurasidone
 
C28H36N4O2S
 
213046 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0980
 
Maraviroc
 
C29H41F2N5O
 
3002977 
Moderate    Inter Info   
[49]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1019
 
Methdilazine
 
C18H20N2S
 
14677 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1848
 
Minoxidil (topical)
 
C9H15N5O
 
4201 
Moderate    Inter Info   
[50], [51]
D1084
 
Molindone
 
C16H24N2O2
 
23897 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[52], [53], [54]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1251
 
Pentoxifylline
 
C13H18N4O3
 
4740 
Moderate    Inter Info   
[55]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Moderate    Inter Info   
[34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [16], [44], [45]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [16], [44], [45]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1437
 
Safinamide
 
C17H19FN2O2
 
131682 
Moderate    Inter Info   
[34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [16], [44], [45]
D1455
 
Selegiline
 
C13H17N
 
26757 
Moderate    Inter Info   
[34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [16], [44], [45]
D1572
 
Thiethylperazine
 
C22H29N3S2
 
5440 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1576
 
Thiothixene
 
C23H29N3O2S2
 
941651 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Moderate    Inter Info   
[34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [16], [44], [45]
D1625
 
Treprostinil
 
C23H34O5
 
6918140 
Moderate    Inter Info   
[29], [32], [33]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D1726
 
Ziprasidone
 
C21H21ClN4OS
 
60854 
Moderate    Inter Info   
[18], [19], [20], [21], [12], [22], [13], [23], [14], [24], [25]
D0711
 
Garlic
 
NA
 
NA
Minor    Inter Info   
[63], [64]
   Increased risk of methemoglobinemia Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1148
 
Nitrous acid
 
HNO2
 
24529 
Major    Inter Info   
[4], [5], [6]
D1338
 
Prilocaine (topical)
 
C13H20N2O
 
4906 
Major    Inter Info   
[7], [8], [9]
D0163
 
Benzocaine (topical)
 
C9H11NO2
 
2337 
Moderate    Inter Info   
[29], [30], [31]
D0339
 
Cinchocaine (topical)
 
C20H29N3O2
 
3025 
Moderate    Inter Info   
[29], [30], [31]
D0377
 
Cocaine (nasal)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[29], [30], [31]
D0378
 
Cocaine (topical)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[29], [30], [31]
D1835
 
Lidocaine (ophthalmic)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[29], [30], [31]
D1852
 
Oxybuprocaine (ophthalmic)
 
C17H28N2O3
 
4633 
Moderate    Inter Info   
[29], [30], [31]
D1870
 
Proparacaine (ophthalmic)
 
C16H26N2O3
 
4935 
Moderate    Inter Info   
[29], [30], [31]
D1904
 
Tetracaine (ophthalmic)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[29], [30], [31]
D1562
 
Tetracaine (topical)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[29], [30], [31]
   Increased risk of nephrotoxicity Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0441
 
Demeclocycline
 
C21H21ClN2O8
 
54680690 
Minor    Inter Info   
[60], [61], [62]
D0530
 
Doxycycline
 
C22H24N2O8
 
54671203 
Minor    Inter Info   
[60], [61], [62]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1429
 
Rosiglitazone
 
C18H19N3O3S
 
77999 
Moderate    Inter Info   
[56], [57], [58]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antihypertensive agents Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0926
 
Licorice
 
C42H62O16Zn
 
163463 
Moderate    Inter Info   
[46], [47], [48]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Moderate    Inter Info   
[59], [16]
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