Drug General Information (ID: DDI4R8B5A7)
Drug Name			Verteporfin		Drug Info		Isosorbide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antianginal Agents
Structure

Mechanism of Verteporfin-Isosorbide Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Verteporfin				Isosorbide
Mechanism		Verteporfin				Interfere with the therapeutic effect of verteporfin by inhibiting the release of procoagulants or vasoactive factors
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Verteporfin when combined with Isosorbide

Recommended Action
Management		If possible, agents such as anticoagulants, thrombolytics, platelet inhibitors, nonsteroidal anti-inflammatory drugs, ginkgo, dong quai, and vasodilators should be discontinued prior to verteporfin therapy. Otherwise, the potential for diminished efficacy of verteporfin should be considered.

References
1	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
2	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.