Drug General Information (ID: DDIA7384TB)
Drug Name			Pentoxifylline		Drug Info		Isosorbide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasodilator Agents				Antianginal Agents
Structure

Mechanism of Pentoxifylline-Isosorbide Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Pentoxifylline				Isosorbide
Mechanism 1		Antihypertensive agent				Antihypertensive agent Guanylate cyclase  Agonist
Key Mechanism Factor 1
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Pentoxifylline and Isosorbide
Mechanism 2		Hypotensive effects				Antihypertensive agent Guanylate cyclase  Agonist
Key Mechanism Factor 2
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Pentoxifylline and Isosorbide

Recommended Action
Management		Caution is advised if pentoxifylline is used in combination with hypotensive agents. Periodic systemic blood pressure monitoring is recommended.

References
1	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.