Drug General Information (ID: DDIN52HC0Y)
Drug Name			Pentoxifylline		Drug Info		Papaverine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasodilator Agents				Vasodilator Agents
Structure

Mechanism of Pentoxifylline-Papaverine Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Pentoxifylline				Papaverine
Mechanism 1		Antihypertensive agent				Hypotensive effects Phosphodiesterase 4D/5A  Inhibitor
Key Mechanism Factor 1
		Factor Name		Phosphodiesterase				Structure Sequence
		Protein Family		Cyclic nucleotide phosphodiesterase family
		Protein Function		Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Pentoxifylline and Papaverine
Mechanism 2		Hypotensive effects				Hypotensive effects Phosphodiesterase 4D/5A  Inhibitor
Key Mechanism Factor 2
		Factor Name		Phosphodiesterase				Structure Sequence
		Protein Family		Cyclic nucleotide phosphodiesterase family
		Protein Function		Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Pentoxifylline and Papaverine

Recommended Action
Management		Caution is advised if pentoxifylline is used in combination with hypotensive agents. Periodic systemic blood pressure monitoring is recommended.

References
1	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.