Details of Drug

Drug General Information (ID: D0337)
Drug Name	Cimetidine
Drug Type	Small molecule
Drug Synonymous	Acibilin; Acinil; Altramet; Brumetidina; Cimal; Cimetadine; Cimetag; Cimetidina; Cimetidinum; Cimetum; Dyspamet; Edalene; Eureceptor; Evicer; Gastrobitan; Gastromet; Histodil; Magicul; Metracin; Peptol; Sigmetadine; Tagamet; Tametin; Tratul; Ulcedin; Ulcedine; Ulcestop; Ulcimet; Ulcofalk; Ulcomedina; Ulcomet; Ulhys; Valmagen; Venopex; Ci metum; Cimetidine Hcl; Tagamet Hb; Biomet400; C 4522; FPF 1002; SKF 92334; Tagamet Hb 200; CIMETIDINE A/AB; Cimetidina [INN-Spanish]; Cimetidinum [INN-Latin]; DRG-0150; SKF-92334; Tagamet (TN); Tagamet HB (TN); Tagamet HB200 (TN); SK&F-92334; Cimetidine (JP15/USP/INN); Cimetidine [USAN:INN:BAN:JAN]; Tagamet, SKF-92334, Tratul, Tametin, Dyspamet, Acinil, Cimetidine; N-Cyano-N'-methyl-[2-[[[5-methyl-1H-imidazol-4-yl]methyl]thio]ethyl]guanidine; N''-Cyano-N-methyl-N'-[2-[(5-methyl-1H-imidazol-4-yl)methylthio]ethyl]guanidine; N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine; N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine; N-cyano-N'-methyl-N''-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine; N-Cyano-N'-Methyl-N''-(2-(((5-Methyl-1H-Imidazol-4-YL)Methyl)Thio)Ethyl) Guanidine; N-Cyano-N'-methyl-N''-(2-(((5-methyl-1 H-imidazol-4-yl) methyl)thio)ethyl)guanidine; N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine; N''-cyano-N-methyl-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)-ethyl)guanidine; 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine; 1-Cyano-2-methyl-3-[2-[[(5-methylimidazol-4-yl)methyl]thio]ethyl]guanidine; 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine; 2-Cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine; 2-Cyano-1-methyl-3-[2-(5-methyl-1H-imidazol-4-yl-methylthio)ethyl]guanidine; 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine; 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine Click to Show/Hide
Disease Class	DA22: Gastro-oesophageal reflux disease
Therapeutic Class	Antiulcer Agents
Structure
Structure	3D Structure		2D Structure
Formula	C10H16N6S
InChI	1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
InChIKey	AQIXAKUUQRKLND-UHFFFAOYSA-N
Canonical SMILES	CC1=C(N=CN1)CSCCNC(=NC)NC#N
External Link
	Pubchem ID	2756
	CAS Number	51481-61-9
	CHEBI ID	3699
	TTD ID	D02DPA
	INTEDE ID	DR2272
	VARIDT ID	DR00037

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM005 Altered gastric pH BM009 Altered absorption (Unspecific) BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM025 Decreased metabolism (Unspecific) BM028 Competitive inhibition of renal tubular secretion BM032 Decreased renal excretion (Unspecific) BM044 Additive myelosuppressive effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM081 Increased risk of ventricular arrhythmias BM091 Antagonize the effect of cholinergic agents
Relation Graph

Full list of drugs interacting with Cimetidine
Affected gastrointestinal absorption
	Altered gastric pH					Drug Num: 50
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[31]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[76], [89]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[9], [90], [91], [92], [93], [94]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[97]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[9], [98]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[161], [162], [163], [164]
D0141		Bacampicillin	C21H27N3O7S	441397	Moderate		Inter Info	[335], [336]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[9], [339]
D0278		Cefditoren	C19H18N6O5S3	9870843	Moderate		Inter Info	[344]
D0288		Cefpodoxime	C15H17N5O6S2	6335986	Moderate		Inter Info	[335], [345], [346], [336]
D0297		Cefuroxime	C16H16N4O8S	5479529	Moderate		Inter Info	[335], [345], [346], [336]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[347]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[161], [162], [163], [164]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[76], [9], [53], [383], [57], [384], [60]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Moderate		Inter Info	[9], [385]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[388]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[76], [9], [435], [436]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[472]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[161], [162], [163], [164]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[161], [162], [163], [164]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[484], [485], [486], [487]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[492], [484], [493], [494], [495], [9], [496], [497], [498], [499]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[9], [500]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[76], [9], [517]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[537]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[161], [162], [163], [164]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[596]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[625]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[161], [162], [163], [164]
D0049		Aluminum hydroxide	AlH3O3	10176082	Minor		Inter Info	[672], [673], [37], [674], [675], [676], [677], [678], [679], [680], [681], [682]
D0133		Axitinib	C22H18N4OS	6450551	Minor		Inter Info	[686]
D0236		Calcium carbonate	CCaO3	10112	Minor		Inter Info	[672], [673], [37], [674], [675], [676], [677], [678], [679], [680], [681], [682]
D0649		Ferrous fumarate	C4H2FeO4	6433164	Minor		Inter Info	[699], [700], [669], [701]
D0650		Ferrous gluconate	C12H22FeO14	23616740	Minor		Inter Info	[699], [700], [669], [701]
D0651		Ferrous sulfate anhydrous	FeO4S	24393	Minor		Inter Info	[699], [700], [669]
D0847		Iron	Fe	23925	Minor		Inter Info	[699], [700], [669]
D0849		Iron protein succinylate	NA	NA	Minor		Inter Info	[699], [700], [669], [701]
D0967		Magaldrate	AlHMgO5S+2	3086011	Minor		Inter Info	[672], [673], [37], [674], [675], [676], [677], [678], [679], [680], [681], [682]
D0968		Magnesium carbonate	CMgO3	11029	Minor		Inter Info	[672], [673], [37], [674], [675], [676], [677], [678], [679], [680], [681], [682]
D0973		Magnesium hydroxide	H2MgO2	14791	Minor		Inter Info	[672], [673], [37], [674], [675], [676], [677], [678], [679], [680], [681], [682]
D0974		Magnesium oxide	MgO	14792	Minor		Inter Info	[672], [673], [37], [674], [675], [676], [677], [678], [679], [680], [681], [682]
D0989		Mecobalamin	C63H91CoN13O14P	10898559	Minor		Inter Info	[706], [707], [708]
D1313		Ponatinib	C29H27F3N6O	24826799	Minor		Inter Info	[76], [718]
D1328		Prasugrel	C20H20FNO3S	6918456	Minor		Inter Info	[719], [378]
D1377		Raltegravir	C20H21FN6O5	54671008	Minor		Inter Info	[720]
D1480		Sodium bicarbonate	CHNaO3	516892	Minor		Inter Info	[672], [673], [37], [674], [675], [676], [677], [678], [679], [680], [681], [682]
D1701		Vismodegib	C19H14Cl2N2O3S	24776445	Minor		Inter Info	[76], [9], [729]
D0395		Cyanocobalamin	C63H88CoN14O14P	5311498	Minor		Inter Info	[733], [706], [707], [734], [708]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[735], [736]
	Altered absorption (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0224		Butabarbital	C10H16N2O3	2479	Minor		Inter Info	[667]
D0225		Butalbital	C11H16N2O3	2481	Minor		Inter Info	[667]
D0071		Amobarbital	C11H18N2O3	2164	Minor		Inter Info	[667]
D1040		Methylphenobarbital	C13H14N2O3	8271	Minor		Inter Info	[667]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[667]
D1340		Primidone	C12H14N2O2	4909	Minor		Inter Info	[667]
D1573		Thiopental	C11H18N2O2S	3000715	Minor		Inter Info	[667]
D1024		Methohexital	C14H18N2O3	9034	Minor		Inter Info	[667]
D1248		Pentobarbital	C11H18N2O3	4737	Minor		Inter Info	[667]
D1453		Secobarbital	C12H18N2O3	5193	Minor		Inter Info	[667]
Affected cellular transport
	Transporter inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[157], [158], [159]
D0412		Dalfampridine	C5H6N2	1727	Moderate		Inter Info	[76], [386], [387]
D1919		Varenicline	C13H13N3	170361	Minor		Inter Info	[727], [728]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 225
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[4], [5], [6], [7], [8]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[17], [18], [19]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[20]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[32], [33]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[71], [72], [73], [74], [75]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[17], [18]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[76], [77]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[78], [79]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[79]
D0947		Loperamide	C29H33ClN2O2	3955	Major		Inter Info	[83], [84], [85], [86], [87], [88]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[95], [76], [9], [90], [96], [33]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [33], [126], [127], [128], [129], [130], [131], [132], [133]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [33], [144], [145]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[146], [147], [148], [149], [150], [151], [152], [153]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[154], [155], [156]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[76], [9], [160]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[4], [5], [6], [7], [8]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D0048		Altretamine	C9H18N6	2123	Moderate		Inter Info	[184], [185]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[186], [76], [9], [187], [188], [189], [190], [191]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[192]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[213], [214], [215]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[216]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [24], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [214], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[278]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[279], [280], [9], [90], [281], [282], [283], [284], [285], [286], [287], [288], [214], [289], [290], [291], [292]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[293]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[294], [37], [295], [296], [297], [298], [299], [300], [199], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[186], [76], [9], [187], [188], [189], [190], [191]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[333]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [24], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [214], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[9], [334]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[337]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[338]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[341]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[342], [343]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[9], [348], [349], [350], [351]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[352], [353], [354], [355], [356], [357], [358], [359], [360]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[186], [76], [9], [187], [188], [189], [190], [191]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [373], [374], [375], [376], [377], [378], [379]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[170], [172], [179]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[380]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[381], [382]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[186], [76], [9], [187], [188], [189], [190], [191]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[76], [9], [389], [390], [214], [391]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[392], [76], [9], [393], [394], [395], [396], [397], [398]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[186], [76], [9], [187], [188], [189], [190], [191]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[406]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[407]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[408]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[409]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[410]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[411], [412], [413]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[414], [415], [416], [417], [418], [24], [419], [411], [420], [412], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [413], [431], [432], [433], [434]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[95], [76], [9], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[447]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[448], [214]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[9], [449], [450]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[467]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[470]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[471]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[473]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[9], [474]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[475]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[9], [476]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[9], [348], [349], [350], [351]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[477], [214]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[478]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[95], [76], [9], [479], [480], [481], [482]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[76], [9], [479]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[483]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[450]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[9], [488]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[489], [490]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[491]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[76], [9], [501]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[503]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[9], [504]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[505], [214]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[506]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[507]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[76], [9], [508], [214]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[509]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[510]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[511]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[512], [513]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[514], [515]
D1088		Moricizine	C22H25N3O4S	34633	Moderate		Inter Info	[516]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[186], [76], [9], [187], [188], [189], [190], [191]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[518]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[9], [519]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[520]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[294], [37], [295], [296], [297], [298], [299], [300], [199], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[522], [523], [76], [524], [525], [526], [527], [396]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[522], [523], [76]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[9], [528]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[529], [390]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[9], [534]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[535], [536]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[538]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[9], [539], [33]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[9], [33], [540]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[541]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[542]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[549]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[550], [551], [552], [553]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[554]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[76], [9], [555]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[556], [557], [558], [559], [560], [561], [562]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[76], [9], [563]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[76], [564]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[565]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[9], [566], [567]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[9], [568]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[569]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[570]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [24], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [214], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[76], [9], [571], [572], [573], [214], [574]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[575]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[576]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[9], [90], [577]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[76], [578]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[76], [9], [571], [572], [573], [214], [574]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[579]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[580], [581], [582]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[583]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[584]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[585]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[587], [588]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[589]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[9], [590], [591]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[76], [9], [592], [54], [60]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[593]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[594]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[595]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[76], [9], [597]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[599]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[600], [601]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[602], [603]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[604], [605]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[606], [607], [608], [609], [610], [611], [33], [612], [613], [614], [615], [616], [617]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[618], [214]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[325], [326], [327]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[619], [620], [621], [622]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[623]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[76], [9], [592], [54], [60]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[186], [76], [9], [187], [188], [189], [190], [191]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[626], [627], [628], [629], [630], [631], [632]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [24], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [214], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[633], [634], [635]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[636], [637], [638], [639], [640], [641], [642], [643]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[411], [412], [413]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[411], [412], [413]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[644], [645], [33], [646], [647]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[95], [76], [9]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[186], [76], [9], [187], [188], [189], [190], [191]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[648], [649], [650], [651]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[294], [37], [295], [296], [297], [298], [299], [300], [199], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[654], [655], [656]
D1728		Zolmitriptan	C16H21N3O2	60857	Moderate		Inter Info	[659]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[660], [661], [662], [663], [664], [665], [666]
D0231		Caffeine	C8H10N4O2	2519	Minor		Inter Info	[668], [669]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[683]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[76], [684], [685]
D0425		Darolutamide	C19H19ClN6O2	67171867	Minor		Inter Info	[688]
D0451		Desvenlafaxine	C16H25NO2	125017	Minor		Inter Info	[689], [690]
D0514		Dolasetron	C19H20N2O3	3033818	Minor		Inter Info	[694]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[695]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[696]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Minor		Inter Info	[702]
D0948		Lopinavir	C37H48N4O5	92727	Minor		Inter Info	[9], [703], [704]
D0982		Mebendazole	C16H13N3O3	4030	Minor		Inter Info	[705]
D0994		Melatonin	C13H16N2O2	896	Minor		Inter Info	[76]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[712], [713], [714], [715]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[716]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[76], [684], [685]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[717]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[721]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[9], [722]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[723]
D1553		Terbinafine	C21H25N	1549008	Minor		Inter Info	[724], [725]
D1587		Tinidazole	C8H13N3O4S	5479	Minor		Inter Info	[712], [713], [714], [715]
D1646		Trimetrexate	C19H23N5O3	5583	Minor		Inter Info	[726]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[738]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[739]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[740], [741], [742], [743], [744], [745], [746]
D1689		Venlafaxine	C17H27NO2	5656	Minor		Inter Info	[689], [690]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[748], [749], [750], [751]
	Non-CYP450 enzyme inhibition					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[598]
D0328		Cholecalciferol	C27H44O	5280795	Minor		Inter Info	[670], [671]
D0617		Ethanol	C2H6O	702	Minor		Inter Info	[697], [698]
D0591		Ergocalciferol	C28H44O	5280793	Minor		Inter Info	[670], [671]
	Decreased metabolism (Unspecific)					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[405]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[530], [531], [532]
D0484		Dienestrol (topical)	C18H18O2	667476	Minor		Inter Info	[691], [692], [693]
D0605		Esterified estrogens	NA	NA	Minor		Inter Info	[691], [692], [693]
D0606		Estradiol	C18H24O2	5757	Minor		Inter Info	[691], [692], [693]
D0607		Estradiol (topical)	C18H24O2	5757	Minor		Inter Info	[691], [692], [693]
D0609		Estrone	C18H22O2	5870	Minor		Inter Info	[691], [692], [693]
D0610		Estrone sulfate	C18H22O5S	3001028	Minor		Inter Info	[691], [692], [693]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Minor		Inter Info	[691], [692], [693]
D0619		Ethinylestradiol	C20H24O2	5991	Minor		Inter Info	[691], [692], [693]
D1011		Mestranol	C21H26O2	6291	Minor		Inter Info	[691], [692], [693]
D1370		Quinestrol	C25H32O2	9046	Minor		Inter Info	[691], [692], [693]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Minor		Inter Info	[691], [692], [693]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Minor		Inter Info	[691], [692], [693]
D0487		Diethylstilbestrol	C18H20O2	448537	Minor		Inter Info	[691], [692], [693]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[533]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[543], [544], [545], [546], [547], [548]
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[624]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[9], [657], [658]
D0998		Memantine	C12H21N	4054	Minor		Inter Info	[709], [710], [711]
D1768		Creatine	C4H9N3O2	586	Minor		Inter Info	[730], [731], [732]
D1061		Midodrine	C12H18N2O4	4195	Minor		Inter Info	[737]
D1631		Triamterene	C12H11N7	5546	Minor		Inter Info	[747]
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0210		Bromfenac	C15H12BrNO3	60726	Minor		Inter Info	[687]
Pharmacodynamic additive effects
	Additive myelosuppressive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0264		Carmustine	C5H9Cl2N3O2	2578	Major		Inter Info	[1], [2], [3]
D0945		Lomustine	C9H16ClN3O2	3950	Major		Inter Info	[80], [81], [82]
	Increased risk of bradycardia					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[76], [99]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[340]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[468], [469]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[502]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[521]
	Increased risk of ventricular arrhythmias					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[76], [9], [586]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[399], [400], [401], [402], [403], [404]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[399], [400], [401], [402], [403], [404]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[399], [400], [401], [402], [403], [404]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[399], [400], [401], [402], [403], [404]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[399], [400], [402], [652], [653], [404]

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264	Product Information. Zocor (simvastatin). Merck & Co, Inc, West Point, PA.
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407	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
408	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
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429	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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467	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
468	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
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471	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
472	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
473	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
474	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
475	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
476	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
477	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
478	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
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482	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
483	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
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488	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
489	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
490	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
491	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
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498	Product Information. Ketoconazole (ketoconazole). Mylan Pharmaceuticals Inc, Morgantown, WV.
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500	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
501	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
502	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
503	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
504	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
505	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
506	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
507	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
508	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
509	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
510	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
511	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
512	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
513	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
514	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
515	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
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517	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
518	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
519	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
520	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
521	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
522	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
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525	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
526	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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528	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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533	Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
534	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
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536	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
537	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
538	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
539	Product Information. Esbriet (pirfenidone). Intermune Inc, Brisbane, CA.
540	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
541	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
542	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
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554	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
555	Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
556	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
557	Hatorp V, Hansen KT, Thomsen MS "Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide." J Clin Pharmacol 43 (2003): 649-60. [PMID: 12817528]
558	Khamaisi M, Leitersdorf E "Severe hypoglycemia from clarithromycin-repaglinide drug interaction." Pharmacotherapy 28 (2008): 682-4. [PMID: 18447665]
559	Niemi M, Neuvonen PJ, Kivisto KT "The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide." Clin Pharmacol Ther 70 (2001): 58-65. [PMID: 11452245]
560	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
561	Tornio A, Niemi M, Neuvonen M, et al. "The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo." Clin Pharmacol Ther 84 (2008): 403-11. [PMID: 18388877]
562	Niemi M, Backman JT, Neuvonen M, Neuvonen PJ "Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide." Diabetologia 46 (2003): 347-51. [PMID: 12687332]
563	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
564	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
565	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
566	Product Information. Daliresp (roflumilast). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
567	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
568	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
569	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
570	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
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572	Product Information. Parlodel (bromocriptine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
573	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
574	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
575	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
576	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
577	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
578	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
579	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
580	Franco-Salinas G, de la Rosette JJ, Michel MC "Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations." Clin Pharmacokinet 49 (2010): 177-88. [PMID: 20170206]
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582	Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT.
583	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
584	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
585	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
586	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
587	Brynne N, Forslund C, Hallen B, Gustafsson LL, Bertilsson L "Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity." Br J Clin Pharmacol 48 (1999): 564-72. [PMID: 10583027]
588	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
589	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
590	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
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593	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
594	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
595	Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ.
596	Product Information. Epclusa (sofosbuvir-velpatasvir). Gilead Sciences, Foster City, CA.
597	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
598	Product Information. Sonata (zaleplon) Wyeth-Ayerst Laboratories, Philadelphia, PA.
599	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
600	Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
601	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
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604	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
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618	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
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621	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
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623	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
624	Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.
625	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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635	Product Information. Demerol (meperidine). Sanofi Winthrop Pharmaceuticals, New York, NY.
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642	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
643	Oda Y, Kharasch ED "Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation." J Pharmacol Exp Ther 298 (2001): 1021-32. [PMID: 11504799]
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645	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
646	Sitsen JM, Maris FA, Timmer CJ "Concomitant use of mirtazapine and cimetidine: a drug-drug interaction study in healthy male subjects." Eur J Clin Pharmacol 56 (2000): 389-94. [PMID: 11009047]
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649	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
650	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
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653	Product Information. Cognex (tacrine). Parke-Davis, Morris Plains, NJ.
654	Edeki TI, He HB, Wood AJJ "Pharmacogenetic explanation for excessive beta-blockade following timolol eye drops: potential for oral-ophthalmic drug interaction." JAMA 274 (1995): 1611-3. [PMID: 7474246]
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657	Canadian Pharmacists Association "e-CPS."
658	Product Information. Sanctura (trospium chloride). Odyssey Pharmaceutical, East Hanover, NJ.
659	Product Information. Zomig (zolmitriptan). Zeneca Pharmaceuticals, Wilmington, DE.
660	Farkas D, Volak L, Harmatz J, von Moltke L, Court M, Greenblatt D "Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem." Clin Pharmacol Ther 85 (2009): 644-50. [PMID: 19242403]
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664	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
665	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
666	Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT "Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects." Br J Clin Pharmacol 63 (2007): 116-20. [PMID: 16822278]
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669	Product Information. Tagamet (cimetidine). SmithKline Beecham, Philadelphia, PA.
670	Odes HS, Fraser GM, Krugliak P, et al "Effect of cimetidine on hepatic vitamin D metabolism in humans." Digestion 46 (1990): 61-4. [PMID: 2253823]
671	Product Information. Fosamax Plus D (alendronate-cholecalciferol). Merck & Company Inc, West Point, PA.
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679	Mihaly GW, Marino AT, Webster LK, Jones DB, Louis WJ, Smallwood RA "High dose of antacid (Mylanta II) reduces bioavailability of ranitidine." Br Med J 285 (1982): 998-9. [PMID: 6289961]
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683	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
684	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
685	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
686	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
687	Product Information. Duract (bromfenac). Wyeth-Ayerst Laboratories, Philadelphia, PA.
688	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
689	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
690	Troy SM, Rudolph R, Mayersohn M, Chiang ST "The influence of cimetidine on the disposition kinetics of the antidepressant venlafaxine." J Clin Pharmacol 38 (1998): 467-74. [PMID: 9602962]
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693	Michnovicz JJ, Galbraith RA "Cimetidine inhibits catechol estrogen metabolism in women." Metabolism 40 (1991): 170-4. [PMID: 1988774]
694	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
695	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
696	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
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701	Rosner F "Cimetidine and iron absorption." Lancet 1 (1978): 95.
702	Simons FE, Sussman GL, Simons KJ "Effect of the H2-antagonist cimetidine on the pharmacokinetics and pharmacodynamics of the H1-antagonists hydroxyzine and cetirizine in patients with chronic urticaria." J Allergy Clin Immunol 95 (1995): 685-93. [PMID: 7897151]
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704	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
705	Bekhti A, Pirotte J "Cimetidine increases serum mebendazole concentrations: implications for treatment of hepatic hydatid cysts." Br J Clin Pharmacol 24 (1987): 390-2. [PMID: 3663452]
706	Dutta SK "Vitamin b-12 malabsorption and omeprazole therapy." J Am Coll Nutr 13 (1994): 544-5. [PMID: 7706583]
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711	Product Information. Namenda (memantine). Forest Pharmaceuticals, St. Louis, MO.
712	Gugler R, Jensen JC "Interaction between cimetidine and metronidazole." N Engl J Med 309 (1983): 1518-9. [PMID: 6646177]
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715	Product Information. Tindamax (tinidazole). Presutti Laboratories Inc, Arlington Heights, IL.
716	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
717	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
718	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
719	Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
720	Product Information. Isentress (raltegravir). Merck & Company Inc, West Point, PA.
721	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
722	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
723	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
724	Long CC, Hill SA, Thomas RC, Johnston A, Smith SG, Kendall F, Finlay AY "Effect of terbinafine on the pharmacokinetics of cyclosporin in humans." J Invest Dermatol 102 (1994): 740-3. [PMID: 8176256]
725	Product Information. Lamisil (terbinafine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
726	Product Information. Neutrexin (trimetrexate). US Bioscience, West Conshohocken, PA.
727	FDA. U.S. Food and Drug Administration "Drug Safety Communications: FDA updates label for stop smoking drug Chantix (varenicline) to include potential alcohol interaction, rare risk of seizures, and studies of side effects on mood, behavior, and thinking. Safety announcement." .
728	Product Information. Chantix (varenicline). Pfizer U.S. Pharmaceuticals Group, New York, NY.
729	Product Information. Erivedge (vismodegib). Genentech, South San Francisco, CA.
730	Colchicine: serious interactions. Prescrire Int 17 (2008): 151-3. [PMID: 19492485]
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737	Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
738	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
739	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
740	Ekstrom G, Gunnarsson UB "Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes." Drug Metab Dispos 24 (1996): 955-61. [PMID: 8886604]
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745	Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
746	Arlander E, Ekstrom G, Alm C, Carrillo JA, Bielenstein M, Bottiger Y, Bertilsson L, Gustafsson LL "Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors." Clin Pharmacol Ther 64 (1998): 484-91. [PMID: 9834040]
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748	Miceli JJ, Smith M, Robarge L, Morse T, Laurent A "The effects of ketoconazole on ziprasidone pharmacokinetics--a placebo-controlled crossover study in healthy volunteers." Br J Clin Pharmacol 49(suppl 1) (2000): s71-6. [PMID: 10771458]
749	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
750	Wilner KD, Hansen RA, Folger CJ, Geoffroy P "The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid." Br J Clin Pharmacol 49(Suppl 1) (2000): 57S-60S. [PMID: 10771455]
751	Prakash C, Kamel A, Cui D, Whalen RD, Miceli JJ, Tweedie D "Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions." Br J Clin Pharmacol 49(Suppl 1) (2000): 35S-42S. [PMID: 10771452]

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