Drug General Information (ID: DDIXR75UE0)
Drug Name			Diethylstilbestrol		Drug Info		Cimetidine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antiulcer Agents
Structure

Mechanism of Diethylstilbestrol-Cimetidine Interaction (Severity Level: Minor)
Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Diethylstilbestrol				Cimetidine
Mechanism		Estradiol				Inhibition of the 2-hydroxylation of estradiol
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Diethylstilbestrol caused by Cimetidine

References
1	Galbraith RA, Michnovicz JJ "The effects of cimetidine on the oxidative metabolism of estradiol." N Engl J Med 321 (1989): 269-74. [PMID: 2747769]
2	Galbraith RA, Michnovicz JJ "The oxidative metabolism of estradiol: inhibition by cimetidine." Trans Assoc Am Physicians 102 (1989): 44-54. [PMID: 2638529]
3	Michnovicz JJ, Galbraith RA "Cimetidine inhibits catechol estrogen metabolism in women." Metabolism 40 (1991): 170-4. [PMID: 1988774]