Drug General Information (ID: DDIB9UVYPZ)
Drug Name			Cimetidine		Drug Info		Estrone sulfate (topical)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Estrogens
Structure

Mechanism of Cimetidine-Estrone sulfate (topical) Interaction (Severity Level: Minor)
Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Cimetidine				Estrone sulfate (topical)
Mechanism		Inhibition of the 2-hydroxylation of estradiol				Estradiol
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Estrone sulfate (topical) caused by Cimetidine

References
1	Galbraith RA, Michnovicz JJ "The effects of cimetidine on the oxidative metabolism of estradiol." N Engl J Med 321 (1989): 269-74. [PMID: 2747769]
2	Galbraith RA, Michnovicz JJ "The oxidative metabolism of estradiol: inhibition by cimetidine." Trans Assoc Am Physicians 102 (1989): 44-54. [PMID: 2638529]
3	Michnovicz JJ, Galbraith RA "Cimetidine inhibits catechol estrogen metabolism in women." Metabolism 40 (1991): 170-4. [PMID: 1988774]