Drug General Information (ID: DDIZXJPC1K)
  Drug Name Pentobarbital Drug Info Cimetidine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Anxiolytics/Sedatives/Hypnotics Antiulcer Agents
  Structure

 Mechanism of Pentobarbital-Cimetidine Interaction (Severity Level: Minor)
     Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Pentobarbital Cimetidine
      Mechanism Decrease the bioavailability of cimetidine Cimetidine
      Key Mechanism Factor 1
Factor Name Pharmacokinetic
Factor Description Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Altered absorption of Cimetidine caused by Pentobarbital 

References
1 Somogyi A, Thielscher S, Gugler R "Influence of phenobarbital treatment on cimetidine kinetics." Eur J Clin Pharmacol 19 (1981): 343-7. [PMID: 7238562]