Details of Drug-Drug Interaction
| Drug General Information (ID: DDIHVKJ2LN) | |||||||||
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| Drug Name | Triamterene | Drug Info | Cimetidine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Diuretics | Antiulcer Agents | |||||||
| Structure | |||||||||
| Mechanism of Triamterene-Cimetidine Interaction (Severity Level: Minor) | |||||||||
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| Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Triamterene | Cimetidine | |||||||
| Mechanism | Triamterene | Inhibit renal tubular secretion of triamterene | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Renal tubular secretion | ||||||||
| Factor Description | Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion. | ||||||||
| Mechanism Description |
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| References | |||||||||||||||||||
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| 1 | Muirhead MR, Somogyi AA, Rolan PE, Bochner F "Effect of cimetidine on renal and hepatic drug elimination: studies with triamterene." Clin Pharmacol Ther 40 (1986): 400-7. [PMID: 3757403] | ||||||||||||||||||