Drug General Information (ID: DDI1QIK0FG)
Drug Name			Conjugated estrogens (topical)		Drug Info		Cimetidine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Estrogens				Antiulcer Agents
Structure

Mechanism of Conjugated estrogens (topical)-Cimetidine Interaction (Severity Level: Minor)
Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Conjugated estrogens (topical)				Cimetidine
Mechanism		Estradiol				Inhibition of the 2-hydroxylation of estradiol
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Conjugated estrogens (topical) caused by Cimetidine

References
1	Galbraith RA, Michnovicz JJ "The effects of cimetidine on the oxidative metabolism of estradiol." N Engl J Med 321 (1989): 269-74. [PMID: 2747769]
2	Galbraith RA, Michnovicz JJ "The oxidative metabolism of estradiol: inhibition by cimetidine." Trans Assoc Am Physicians 102 (1989): 44-54. [PMID: 2638529]
3	Michnovicz JJ, Galbraith RA "Cimetidine inhibits catechol estrogen metabolism in women." Metabolism 40 (1991): 170-4. [PMID: 1988774]