Details of Drug

Drug General Information (ID: D0388)
Drug Name	Conjugated estrogens (topical)
Drug Type	Small molecule
Drug Synonymous	Par Estro; evex; Premarin; Conestoral; NSC18313; Sodium estrone 3-monosulfate; Estrone, hydrogen sulfate sodium salt; AC1NS0NL; NSC-18313; sodium [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate; Estra-1,5(10)-trien-17-one, 3-(sulfooxy)-, sodium; Carentil; Congest; Estroplus; Evex; Menotabs; Oestrogen; Prelestrin; Presomil; Progens; Conjugated Equine Estrogens; Conjugated Estrogenic Substances; Conjugated estrogenic hormones; Conjugated oestrogens; Conjugated oestrogens [Steroidal oestrogens]; Steroidal estrogens; ASTA Medica Brand of Estrogens, Conjugated; Almirall Brand of Estrogens, Conjugated; Equine Estrogens, Conjugated; Estro-Feminal; Estrogenic Hormones, Conjugated; Estrogenic substances, conjugated; Estrogens, conjugated USP; Estrogens, conjugated [USP]; Estrogens, conjugated synthetic A; Estrogens, steroidal; Solvay Brand of Estrogens, Conjugated; Trianon Brand of Estrogens, Conjugated; Wyeth Brand of Estrogens, Conjugated; Estrogens, conjugated (USP); Estrogens, conjugated-equine; Mack Brand of Estrogens, Conjugated (USP); Major Brand of Estrogens, Conjugated (USP); Pasadena Brand of Estrogens, Conjugated (USP); Pharmacia Brand of Estrogens, Conjugated (USP); CES; Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, sodium salt; Sodium [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate Click to Show/Hide
Disease Class	GA30: Menopausal disorder; CA08: Vasomotor/allergic rhinitis
Therapeutic Class	Estrogens
Structure
Structure	3D Structure		2D Structure
Formula	C18H21NaO5S
InChI	1S/C18H22O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14?,15?,16?,18-;/m0./s1
InChIKey	VUCAHVBMSFIGAI-TWCWWGPMSA-M
Canonical SMILES	CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)[O-].[Na+]
External Link
	Pubchem ID	45357473
	TTD ID	D0T0LU

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM015 Increase globulin concentration BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM023 UGT induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM047 Additive thrombogenic effects BM055 Increased risk of hepatotoxicity BM079 Increased risk of skin rash BM085 Antagonize the effect of antithrombotic agents BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM094 Antagonize the effect of estrogen BM107 Attenuated pharmacological effects (Unspecific) BM108 Increased risk of hypercalcemia
Relation Graph

Full list of drugs interacting with Conjugated estrogens (topical)
Affected cellular transport
Affected organization distribution
	Increase globulin concentration					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[35], [36], [37]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[35], [36], [37]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[35], [36], [37]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[35], [36], [37]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[35], [36], [37]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[35], [36], [37]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[35], [36], [37]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[63], [64], [65]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[35], [36], [37]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[35], [36], [37]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[35], [36], [37]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[35], [36], [37]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[35], [36], [37]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[35], [36], [37]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[63], [64], [65]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[24], [25], [26]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[33], [34]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[38]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[2], [3], [39]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[5], [43]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[44], [45]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[46], [47], [48]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[49], [50]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[33], [34]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[3], [49], [55]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[24], [25], [26]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[56], [57], [58]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[24], [25], [26]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[2], [3], [62]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[66]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[24], [25], [26]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[3], [67], [68]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[69], [70], [71]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[24], [25], [26]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[2], [72], [73]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[74]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[75], [71], [76]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[24], [25], [26]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[2], [3], [39]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[24], [25], [26]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[83], [84], [71]
D0120		Atorvastatin	C33H35FN2O5	60823	Minor		Inter Info	[88], [58]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[92], [93], [94]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[96], [97]
	UGT inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1227		Paritaprevir	C40H43N7O7S	45110509	Major		Inter Info	[10], [11]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[79], [80], [81], [82]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[2], [53], [54]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[2], [53], [54]
	Decreased metabolism (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Minor		Inter Info	[85], [86], [87]
D0072		Amoxapine	C17H16ClN3O	2170	Minor		Inter Info	[85], [86], [87]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[89], [90], [91]
D0361		Clomipramine	C19H23ClN2	2801	Minor		Inter Info	[85], [86], [87]
D0446		Desipramine	C18H22N2	2995	Minor		Inter Info	[85], [86], [87]
D0525		Doxepin	C19H21NO	667477	Minor		Inter Info	[85], [86], [87]
D0795		Imipramine	C19H24N2	3696	Minor		Inter Info	[85], [86], [87]
D1158		Nortriptyline	C19H21N	4543	Minor		Inter Info	[85], [86], [87]
D1361		Protriptyline	C19H21N	4976	Minor		Inter Info	[85], [86], [87]
D1647		Trimipramine	C20H26N2	5584	Minor		Inter Info	[85], [86], [87]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[1], [2], [3]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[3], [8], [9]
D1312		Pomalidomide	C13H11N3O4	134780	Major		Inter Info	[12], [13], [14]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[3], [12], [15]
D1619		Tranexamic acid	C8H15NO2	5526	Major		Inter Info	[16], [17], [18]
D0385		Conestat alfa	NA	NA	Moderate		Inter Info	[40], [41], [42]
D0762		Human C1-esterase inhibitor	NA	NA	Moderate		Inter Info	[40], [41], [42]
	Increased risk of hepatotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0417		Dantrolene	C14H10N4O5	6914273	Major		Inter Info	[4], [5], [6]
	Increased risk of skin rash					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[77], [78]
	Increased risk of hypercalcemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1754		Calcitriol (topical)	C27H44O3	5280453	Moderate		Inter Info	[22], [23]
D1753		Calcipotriol (topical)	C27H40O3	5288783	Moderate		Inter Info	[22], [23]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[30], [31], [32]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[30], [31], [32]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[30], [31], [32]
	Antagonize the effect of antidiabetic agents					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[19], [20], [21]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[19], [20], [21]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[19], [20], [21]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[19], [20], [21]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[19], [20], [21]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[19], [20], [21]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[19], [20], [21]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[19], [20], [21]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[19], [20], [21]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[19], [20], [21]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[19], [20], [21]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[19], [20], [21]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[19], [20], [21]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[19], [20], [21]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[19], [20], [21]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[19], [20], [21]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[19], [20], [21]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[19], [20], [21]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[19], [20], [21]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[19], [20], [21]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[19], [20], [21]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[19], [20], [21]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[19], [20], [21]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[19], [20], [21]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[19], [20], [21]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[19], [20], [21]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[19], [20], [21]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[19], [20], [21]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[19], [20], [21]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[19], [20], [21]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[19], [20], [21]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [20], [21]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [20], [21]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [20], [21]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [20], [21]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [20], [21]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [20], [21]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[19], [20], [21]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[19], [20], [21]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[19], [20], [21]
	Antagonize the effect of antihypertensive agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[19], [20], [21]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[19], [20], [21]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[19], [20], [21]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[19], [20], [21]
	Antagonize the effect of estrogen					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1885		Saw palmetto	NA	NA	Minor		Inter Info	[95], [45], [52]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0752		Hemin	C34H32FeN4O4	26945	Major		Inter Info	[7]
D0086		Anastrozole	C17H19N5	2187	Moderate		Inter Info	[27], [28], [29]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[51], [45], [52]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[27], [28], [29]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[59], [60], [61]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[27], [28], [29]
D1557		Testolactone	C19H24O3	13769	Moderate		Inter Info	[27], [28], [29]

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