Drug General Information (ID: DDIR9HK6Z8)
Drug Name			Conjugated estrogens (topical)		Drug Info		Testolactone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Estrogens				Antineoplastics
Structure

Mechanism of Conjugated estrogens (topical)-Testolactone Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Conjugated estrogens (topical)				Testolactone
Mechanism		Decrease the therapeutic effect of aromatase inhibitor				Aromatase inhibitor
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Conjugated estrogens (topical) when combined with Testolactone

Recommended Action
Management		Use of estrogen-containing products should be avoided during aromatase inhibitor therapy.

References
1	Product Information. Aromasin (exemestane) Pharmacia &amp Upjohn, Kalamazoo, MI.
2	Product Information. Femara (letrozole). Novartis Pharmaceuticals, East Hanover, NJ.
3	Product Information. Arimidex (anastrozole). Zeneca Pharmaceuticals, Wilmington, DE.