Drug General Information (ID: DDI54GLYCA)
Drug Name			Conjugated estrogens (topical)		Drug Info		Saw palmetto		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Estrogens				Herbal Products

Mechanism of Conjugated estrogens (topical)-Saw palmetto Interaction (Severity Level: Minor)
Antagonize the effect of estrogen Click to Show/Hide Mechanism Graph
Drug Name		Conjugated estrogens (topical)				Saw palmetto
Mechanism 1		Estrogen agent				Antiestrogenic effects
Key Mechanism Factor 1
		Factor Name		Estrogen
		Factor Description		The efficacy of estrogenic medications may be reduced, such as contraceptive failure due to reduced efficacy of estrogen-containing contraceptives.
Mechanism Description		Antagonize the effect of Conjugated estrogens (topical) when combined with Saw palmetto
Mechanism 2		Estrogen agent				Antiestrogenic effects
Key Mechanism Factor 2
		Factor Name		Estrogen
		Factor Description		The efficacy of estrogenic medications may be reduced, such as contraceptive failure due to reduced efficacy of estrogen-containing contraceptives.
Mechanism Description		Antagonize the effect of Conjugated estrogens (topical) when combined with Saw palmetto

References
1	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
2	Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24. [PMID: 8751044]
3	Weber A, Jager R, Borner A, et al. "Can grapefruit juice influence ethinyl estradiol bioavailability?" Contraception 53 (1996): 41-7. [PMID: 8631189]