Drug General Information (ID: DDIOPV0QBF)
Drug Name			Conjugated estrogens (topical)		Drug Info		Calcipotriol (topical)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Estrogens				Antipsoriatic Agents
Structure

Mechanism of Conjugated estrogens (topical)-Calcipotriol (topical) Interaction (Severity Level: Moderate)
Increased risk of hypercalcemia Click to Show/Hide Mechanism Graph
Drug Name		Conjugated estrogens (topical)				Calcipotriol (topical)
Mechanism		Hypercalcemia				Hypercalcemia
Key Mechanism Factor 1
		Factor Name		Hypercalcemia
		Factor Description		Hypercalcemia is a condition in which the calcium level in your blood is above normal. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work.
Mechanism Description		Increased risk of hypercalcemia by the combination of Conjugated estrogens (topical) and Calcipotriol (topical)

Recommended Action
Management		Calcium and vitamin D status should be monitored closely when topical vitamin D analogs are used in combination with systemic vitamin D products or other agents that can increase serum calcium levels.

References
1	Product Information. Vectical (calcitriol topical). Galderma Laboratories Inc, Cranbury, NJ.
2	Product Information. Dovonex (calcipotriene). Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.