Drug General Information (ID: DDIJTXI18F)
Drug Name			Cimetidine		Drug Info		Iron protein succinylate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Iron Supplement

Mechanism of Cimetidine-Iron protein succinylate Interaction (Severity Level: Minor)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Cimetidine				Iron protein succinylate
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Iron protein succinylate due to altered gastric pH caused by Cimetidine

References
1	Bianchi FM, Cavassini GB, Leo P "Iron protein succynilate in the treatment of iron deficiency: potential interaction with H2-receptor antagonists." Int J Clin Pharmacol Ther Toxicol 31 (1993): 209-17. [PMID: 8100220]
2	Partlow ES, Campbell NRC, Chan SC, Pap KM, Granberg K, Hasinoff BB "Ferrous sulfate does not reduce serum levels of famotidine or cimetidine after concurrent ingestion." Clin Pharmacol Ther 59 (1996): 389-93. [PMID: 8612382]
3	Product Information. Tagamet (cimetidine). SmithKline Beecham, Philadelphia, PA.
4	Rosner F "Cimetidine and iron absorption." Lancet 1 (1978): 95.