Details of Drug

Drug General Information (ID: D0101)
Drug Name	Arbutamine
Drug Type	Small molecule
Drug Synonymous	Arbutamina; Arbutaminum; Genesa; Arbutamina [INN-Spanish]; Arbutamine [INN:BAN]; Arbutaminum [INN-Latin]; 4-[(1R)-1-hydroxy-2-[4-(4-hydroxyphenyl)butylamino]ethyl]benzene-1,2-diol; 4-[(1R)-1-hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]benzene-1,2-diol; 4-[1-hydroxy-2-[4-(4-hydroxyphenyl)butylamino]ethyl]benzene-1,2-diol Click to Show/Hide
Disease Class	BA80: Coronary atherosclerosis
Therapeutic Class	Cardiotonic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C18H23NO4
InChI	1S/C18H23NO4/c20-15-7-4-13(5-8-15)3-1-2-10-19-12-18(23)14-6-9-16(21)17(22)11-14/h4-9,11,18-23H,1-3,10,12H2/t18-/m0/s1
InChIKey	IIRWWTKISYTTBL-SFHVURJKSA-N
Canonical SMILES	C1=CC(=CC=C1CCCCNCC(C2=CC(=C(C=C2)O)O)O)O
External Link
	Pubchem ID	60789
	CAS Number	128470-16-6
	CHEBI ID	50580
	TTD ID	D06KYN

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM078 Increased risk of rapid heart rate BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Arbutamine
Pharmacodynamic additive effects
	Increased risk of rapid heart rate					Drug Num: 46
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[1], [2], [3]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[3]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[3]
D0010		Acebutolol	C18H28N2O4	1978	Major		Inter Info	[1], [2], [3]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3]
D0200		Bretylium	C11H17BrN+	2431	Major		Inter Info	[1], [2], [3]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[3]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[3]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[3]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1], [2], [3]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1], [2], [3]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3]
D0602		Esmolol	C16H25NO4	59768	Major		Inter Info	[1], [2], [3]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[3]
D0927		Lidocaine	C14H22N2O	3676	Major		Inter Info	[1], [2], [3]
D1054		Mexiletine	C11H17NO	4178	Major		Inter Info	[1], [2], [3]
D1088		Moricizine	C22H25N3O4S	34633	Major		Inter Info	[1], [2], [3]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[3]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [2], [3]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3]
D1357		Propranolol	C16H21NO2	4946	Major		Inter Info	[1], [2], [3]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[3]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2], [3]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[3]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[1], [2], [3]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[3]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[3]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[3]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[3]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[3]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[3]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[3]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[3]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[3]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[3]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[3]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[3]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[3]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[3]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[3]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[3]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[3]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[3]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[3]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[3]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[3]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[3]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[3]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[3]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[3]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[3]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[3]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[3]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[3]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[3]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[3]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[3]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[3]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[3]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Major		Inter Info	[4], [5], [3]

References
1	Ace LN, Jaffe JM, Kunka RL "Effect of food and an antacid on quinidine bioavailability." Biopharm Drug Dispos 4 (1983): 183-90. [PMID: 6882885]
2	Min DI, Ku YM, Geraets DR, Lee HC "Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers." J Clin Pharmacol 36 (1996): 469-76. [PMID: 8739026]
3	Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA.
4	Becquemont L, Verstuyft C, Kerb R, et al. "Effect of grapefruit juice on digoxin pharmacokinetics in humans." Clin Pharmacol Ther 70 (2001): 311-6. [PMID: 11673746]
5	Darcy PF "Nutrient-drug interactions." Adverse Drug React Toxicol Rev 14 (1995): 233-54. [PMID: 8845456]

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