Drug General Information (ID: DDIZWPXR7D)
Drug Name			Digoxin		Drug Info		Arbutamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Cardiotonic Agents
Structure

Mechanism of Digoxin-Arbutamine Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Digoxin				Arbutamine
Mechanism		Bradycardia				Tachycardia
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Digoxin when combined with Arbutamine

Recommended Action
Management		The manufacturer states that these two drugs should not be coadministered.

References
1	Becquemont L, Verstuyft C, Kerb R, et al. "Effect of grapefruit juice on digoxin pharmacokinetics in humans." Clin Pharmacol Ther 70 (2001): 311-6. [PMID: 11673746]
2	Darcy PF "Nutrient-drug interactions." Adverse Drug React Toxicol Rev 14 (1995): 233-54. [PMID: 8845456]
3	Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA.