Details of Drug-Drug Interaction
| Drug General Information (ID: DDIFKAV941) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Amoxapine | Drug Info | Arbutamine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antidepressants | Cardiotonic Agents | |||||||
| Structure | |||||||||
| Mechanism of Amoxapine-Arbutamine Interaction (Severity Level: Major) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of rapid heart rate Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Amoxapine | Arbutamine | |||||||
| Mechanism | Increased heart rate | Increased heart rate | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Tachycardia | ||||||||
| Factor Description | A faster-than-normal heart rate, but the heart is beating normally. Tachycardia may not cause any symptoms or complications, but if left untreated, some forms of tachycardia can lead to serious health problems, including heart failure, stroke, or sudden cardiac death. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Arbutamine should not be administered to patients also receiving tricyclic antidepressants. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA. | ||||||||||||||||||