Details of Drug Interaction | MecDDI

Drug General Information (ID: DDIAKQ0J94)
Drug Name			Arbutamine		Drug Info		Metipranolol (ophthalmic)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cardiotonic Agents				Antihypertensive Agents
Structure

Mechanism of Arbutamine-Metipranolol (ophthalmic) Interaction (Severity Level: Moderate)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph

Drug Name		Arbutamine				Metipranolol (ophthalmic)
Mechanism		Hypertensive effects Beta-1 adrenergic receptor Agonist				Antihypertensive agent Beta adrenergic receptor Antagonist
Key Mechanism Factor 1
		Factor Name		Adrenergic receptor beta-1				× Structure Sequence MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
		Gene Name		ADRB1
		Uniprot ID		ADRB1_HUMAN
		KEGG Pathway		hsa:153
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062). Click to Show/Hide
Key Mechanism Factor 2
		Factor Name		Adrenergic receptor beta				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062). Click to Show/Hide
Mechanism Description		Antagonize the effect of Metipranolol (ophthalmic) when combined with Arbutamine

Recommended Action
Management		Beta-blockers should be discontinued at least 48 hours before arbutamine is administered.

References
1	Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA.