Details of Drug-Drug Interaction
| Drug General Information (ID: DDILTY7B5Q) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Arbutamine | Drug Info | Belladonna | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Cardiotonic Agents | Anticholinergic Agents/Antispasmodics | |||||||
| Structure | |||||||||
| Mechanism of Arbutamine-Belladonna Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of rapid heart rate Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Arbutamine | Belladonna | |||||||
| Mechanism | Increased heart rate | Increased heart rate | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Tachycardia | ||||||||
| Factor Description | A faster-than-normal heart rate, but the heart is beating normally. Tachycardia may not cause any symptoms or complications, but if left untreated, some forms of tachycardia can lead to serious health problems, including heart failure, stroke, or sudden cardiac death. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | As the dosing of arbutamine is based on the heart rate response of the patient, the concomitant use of atropine or other anticholinergic agents should be avoided. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA. | ||||||||||||||||||