Drug General Information (ID: DDIDHVPKIW)
Drug Name			Tolterodine		Drug Info		Arbutamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antispasmodics				Cardiotonic Agents
Structure

Mechanism of Tolterodine-Arbutamine Interaction (Severity Level: Moderate)
Increased risk of rapid heart rate Click to Show/Hide Mechanism Graph
Drug Name		Tolterodine				Arbutamine
Mechanism		Increased heart rate				Increased heart rate
Key Mechanism Factor 1
		Factor Name		Tachycardia
		Factor Description		A faster-than-normal heart rate, but the heart is beating normally. Tachycardia may not cause any symptoms or complications, but if left untreated, some forms of tachycardia can lead to serious health problems, including heart failure, stroke, or sudden cardiac death.
Mechanism Description		Increased risk of rapid heart rate by the combination of Tolterodine and Arbutamine

Recommended Action
Management		As the dosing of arbutamine is based on the heart rate response of the patient, the concomitant use of atropine or other anticholinergic agents should be avoided.

References
1	Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA.