Details of Drug

Drug General Information (ID: D1607)
Drug Name	Tolterodine
Drug Type	Small molecule
Drug Synonymous	Tolterodina; Tolterodinum; Detrol (TN); Detrusitol (TN); Kabi-2234; 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol; 2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol; 2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol; 2-{(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl}-4-methylphenol Click to Show/Hide
Disease Class	GC50: Functional bladder disorder
Therapeutic Class	Antispasmodics
Structure
Structure	3D Structure		2D Structure
Formula	C22H31NO
InChI	1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1
InChIKey	OOGJQPCLVADCPB-HXUWFJFHSA-N
Canonical SMILES	CC1=CC(=C(C=C1)O)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2
External Link
	Pubchem ID	443879
	CAS Number	124937-51-5
	CHEBI ID	9622
	TTD ID	D0BZ7W

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM007 Affecting drug dissolution BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM033 Additive anticholinergic effects BM035 Additive antimotility effects BM038 Additive CNS depression effects BM054 Increased risk of GI mucosal injury/bleeding risk BM061 Increased risk of hyperpyrexia BM078 Increased risk of rapid heart rate BM091 Antagonize the effect of cholinergic agents BM101 Antagonize the effects of beta receptor blockers BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Tolterodine
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[112], [113], [114], [115], [116], [117]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D0011		Acetaminophen	C8H9NO2	1983	Minor		Inter Info	[55], [131], [132]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Minor		Inter Info	[133], [134]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Minor		Inter Info	[133], [134]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Minor		Inter Info	[133], [134]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Minor		Inter Info	[133], [134]
D0491		Digoxin	C41H64O14	2724385	Minor		Inter Info	[137], [138], [139], [140], [141]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Minor		Inter Info	[133], [134]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Minor		Inter Info	[133], [134]
D0798		Indapamide	C16H16ClN3O3S	3702	Minor		Inter Info	[133], [134]
D1048		Metolazone	C16H16ClN3O3S	4170	Minor		Inter Info	[133], [134]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Minor		Inter Info	[149], [150]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Minor		Inter Info	[133], [134]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Minor		Inter Info	[133], [134]
	Affecting drug dissolution					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1146		Nitroglycerin	C3H5N3O9	4510	Minor		Inter Info	[151]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 103
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[51], [52]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[51], [52]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[51], [52]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[51], [52]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[51], [52]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[51], [52]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[51], [52]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[51], [52]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[51], [52]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[51], [52]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[51], [52]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[51], [52]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[51], [52]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[51], [52]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[51], [52]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[51], [52]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[53], [33], [86], [87]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[51], [52]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[51], [52]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[96]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[51], [52]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[51], [52]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[99]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[51], [52]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[51], [52]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[51], [52]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[51], [52]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[51], [52]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[51], [52]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[51], [52]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[51], [52]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[51], [52]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[103], [104]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[51], [52]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[51], [52]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[51], [52]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[51], [52]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[51], [52]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[51], [52]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[110]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[51], [52]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[51], [52]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[51], [52]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[51], [52]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[51], [52]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[51], [52]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[111]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[51], [52]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[51], [52]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[51], [52]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[51], [52]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[51], [52]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[51], [52]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[122]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[51], [52]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[51], [52]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[51], [52]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[51], [52]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[51], [52]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[51], [52]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[51], [52]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[51], [52]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[51], [52]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[51], [52]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[51], [52]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[51], [52]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[51], [52]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[51], [52]
D0298		Celecoxib	C17H14F3N3O2S	2662	Minor		Inter Info	[135], [52], [136]
D0320		Chloroquine	C18H26ClN3	2719	Minor		Inter Info	[135], [52], [136]
D0338		Cinacalcet	C22H22F3N	156419	Minor		Inter Info	[135], [52], [136]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[135], [52], [136]
D0356		Clobazam	C16H13ClN2O2	2789	Minor		Inter Info	[135], [52], [136]
D0539		Duloxetine	C18H19NOS	60835	Minor		Inter Info	[135], [52], [136]
D0641		Fenfluramine	C12H16F3N	3337	Minor		Inter Info	[135], [52], [136]
D0676		Fluoxetine	C17H18F3NO	3386	Minor		Inter Info	[135], [52], [136]
D0713		Gefitinib	C22H24ClFN4O3	123631	Minor		Inter Info	[135], [52], [136]
D1229		Paroxetine	C19H20FNO3	43815	Minor		Inter Info	[135], [52], [136]
D1371		Quinidine	C20H24N2O2	441074	Minor		Inter Info	[135], [52], [136]
D1372		Quinine	C20H24N2O2	3034034	Minor		Inter Info	[135], [52], [136]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[135], [52], [136]
D1553		Terbinafine	C21H25N	1549008	Minor		Inter Info	[135], [52], [136]
D1581		Ticlopidine	C14H14ClNS	5472	Minor		Inter Info	[135], [52], [136]
D0007		Abiraterone	C24H31NO	132971	Minor		Inter Info	[135], [52], [136]
D0220		Bupropion	C13H18ClNO	444	Minor		Inter Info	[135], [52], [136]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Minor		Inter Info	[135], [52], [136]
D0457		Dexfenfluramine	C12H16F3N	66265	Minor		Inter Info	[135], [52], [136]
D0559		Eliglustat	C23H36N2O4	23652731	Minor		Inter Info	[135], [52], [136]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[135], [52], [136]
D0724		Givosiran	C78H139N11O30	119058042	Minor		Inter Info	[135], [52], [136]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Minor		Inter Info	[135], [52], [136]
D0735		Goldenseal	NA	NA	Minor		Inter Info	[135], [52], [136]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Minor		Inter Info	[135], [52], [136]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Minor		Inter Info	[135], [52], [136]
D0952		Lorcaserin	C11H14ClN	11658860	Minor		Inter Info	[135], [52], [136]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Minor		Inter Info	[135], [52]
D1194		Oxamniquine	C14H21N3O3	4612	Minor		Inter Info	[135], [52], [136]
D1221		Panobinostat	C21H23N3O2	6918837	Minor		Inter Info	[135], [52], [136]
D1339		Primaquine	C15H21N3O	4908	Minor		Inter Info	[135], [52], [136]
D1353		Propafenone	C21H27NO3	4932	Minor		Inter Info	[135], [52], [136]
D1423		Rolapitant	C25H26F6N2O2	10311306	Minor		Inter Info	[135], [52], [136]
D1461		Sertraline	C17H17Cl2N	68617	Minor		Inter Info	[135], [52], [136]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Minor		Inter Info	[135], [52], [136]
	CYP450 enzyme induction					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[75]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[53], [33], [88], [89]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[90], [91], [92]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[53], [33], [95]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[33], [97]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[100]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[101]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[33], [102]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[53], [105]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[107], [53], [33], [108]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[109]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[118]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[33], [123]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[126], [127]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[33], [128]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[53], [33], [95]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[53], [33], [129], [95]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[33], [130]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[144], [145], [146], [147], [148]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[144], [145], [146], [147], [148]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[93], [94]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[93], [94]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[93], [94]
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 96
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0051		Amantadine	C10H17N	2130	Moderate		Inter Info	[34], [35]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[41], [43], [49]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0196		Botulinum toxin type A	NA	NA	Moderate		Inter Info	[60], [61], [62]
D0197		Botulinum Toxin Type B	NA	NA	Moderate		Inter Info	[60], [61], [62]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[41], [43], [49]
D0734		Glycopyrronium (topical)	C19H28NO3+	3494	Moderate		Inter Info	[77], [78], [79]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0842		Ipratropium	C20H30NO3+	657309	Moderate		Inter Info	[80], [77], [81], [78], [79], [82], [83], [84]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0019		Aclidinium	C26H30NO4S2+	11434515	Moderate		Inter Info	[80], [77], [81], [78], [79], [82], [83], [84]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[41], [43], [49]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[41], [43], [49]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0998		Memantine	C12H21N	4054	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[41], [43], [49]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[41], [43], [49]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[80], [77], [81], [78], [79], [82], [83], [84]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1590		Tiotropium	C19H22NO4S2+	5487427	Moderate		Inter Info	[80], [77], [81], [78], [79], [82], [83], [84]
D1665		Umeclidinium	C29H34NO2+	11519070	Moderate		Inter Info	[80], [77], [81], [78], [79], [82], [83], [84]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50]
D0843		Ipratropium (nasal)	C20H30NO3+	657309	Minor		Inter Info	[56], [142], [143]
	Additive antimotility effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[85]
	Additive CNS depression effects					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[13]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[14]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[17], [15], [16]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[76]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[26], [27], [17], [19], [21], [20], [23], [24], [31], [22], [25], [29], [15], [30], [32], [33], [28], [16], [18]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[26], [27], [17], [19], [21], [20], [23], [24], [31], [22], [25], [29], [15], [30], [32], [33], [28], [16], [18]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[17], [15], [16]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[53], [33], [57], [55], [56], [54]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[26], [27], [17], [19], [21], [20], [23], [24], [31], [22], [25], [29], [15], [30], [32], [33], [28], [16], [18]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[33], [53], [54], [55], [56], [57]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[17], [15], [16]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[17], [15], [16]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[17], [15], [16]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1183		Opium	NA	NA	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[1], [2], [3]
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[1], [4], [2], [5], [6], [3], [7], [8], [9], [10], [11], [12]
	Increased risk of rapid heart rate					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0101		Arbutamine	C18H23NO4	60789	Moderate		Inter Info	[98]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[33], [106]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[121]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0175		Bethanechol	C7H17N2O2+	2370	Moderate		Inter Info	[58], [59]
D0256		Carbamoylcholine (ophthalmic)	C6H15N2O2+	2551	Moderate		Inter Info	[63], [64]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[58], [59]
D0440		Demecarium (ophthalmic)	C32H52N4O4+2	5966	Moderate		Inter Info	[63], [64]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73]
D0552		Edrophonium	C10H16NO+	3202	Moderate		Inter Info	[74]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73]
D0746		Guanidine	CH5N3	3520	Moderate		Inter Info	[74]
D0856		Isoflurophate (ophthalmic)	C6H14FO3P	5936	Moderate		Inter Info	[63], [64]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73]
D1286		Physostigmine (ophthalmic)	C15H21N3O2	5983	Moderate		Inter Info	[63], [64]
D1365		Pyridostigmine	C9H13N2O2+	4991	Moderate		Inter Info	[74]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73]
D0015		Acetylcholine	C7H16NO2+	187	Moderate		Inter Info	[63], [64]
D0052		Ambenonium	C28H42Cl2N4O2+2	2131	Moderate		Inter Info	[74]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Moderate		Inter Info	[63], [64]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[119], [120]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[74]
D1288		Pilocarpine	C11H16N2O2	5910	Moderate		Inter Info	[58], [59]
D1289		Pilocarpine (ophthalmic)	C11H16N2O2	5910	Moderate		Inter Info	[63], [64]
D1362		Prucalopride	C18H26ClN3O3	3052762	Moderate		Inter Info	[124], [125]

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