Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIO4QMPG5)
  Drug Name Arbutamine Drug Info Levobunolol (ophthalmic) Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Cardiotonic Agents Sympatholytics
  Structure

 Mechanism of Arbutamine-Levobunolol (ophthalmic) Interaction (Severity Level: Moderate)
     Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Arbutamine Levobunolol (ophthalmic)
      Mechanism Hypertensive effects
Beta-1 adrenergic receptor  Agonist 		Antihypertensive agent
Beta adrenergic receptor  Antagonist
      Key Mechanism Factor 1
Factor Name Adrenergic receptor beta-1
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Structure Sequence
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
Gene Name ADRB1
Uniprot ID ADRB1_HUMAN
KEGG Pathway hsa:153
Protein Family G-protein coupled receptor 1 family
Protein Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062).
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      Key Mechanism Factor 2
Factor Name Adrenergic receptor beta Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062).
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      Mechanism Description
  • Antagonize the effect of Levobunolol (ophthalmic) when combined with Arbutamine 

Recommended Action
      Management Beta-blockers should be discontinued at least 48 hours before arbutamine is administered.

References
1 Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA.