Drug General Information (ID: DDIJX1N0GU)
Drug Name			Arbutamine		Drug Info		Flecainide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cardiotonic Agents				Antiarrhythmic Agents
Structure

Mechanism of Arbutamine-Flecainide Interaction (Severity Level: Major)
Increased risk of rapid heart rate Click to Show/Hide Mechanism Graph
Drug Name		Arbutamine				Flecainide
Mechanism		Increased heart rate				Increased heart rate
Key Mechanism Factor 1
		Factor Name		Tachycardia
		Factor Description		A faster-than-normal heart rate, but the heart is beating normally. Tachycardia may not cause any symptoms or complications, but if left untreated, some forms of tachycardia can lead to serious health problems, including heart failure, stroke, or sudden cardiac death.
Mechanism Description		Increased risk of rapid heart rate by the combination of Arbutamine and Flecainide

Recommended Action
Management		The manufacturer recommends that arbutamine not be given concurrently with proarrhythmic drugs.

References
1	Ace LN, Jaffe JM, Kunka RL "Effect of food and an antacid on quinidine bioavailability." Biopharm Drug Dispos 4 (1983): 183-90. [PMID: 6882885]
2	Min DI, Ku YM, Geraets DR, Lee HC "Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers." J Clin Pharmacol 36 (1996): 469-76. [PMID: 8739026]
3	Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA.