Details of Drug

Drug General Information (ID: D0040)
Drug Name	Allopurinol
Drug Type	Small molecule
Drug Synonymous	Adenock; Ailural; Ailurial; Allohexal; Allohexan; Alloprin; Allopur; Allopurin; Allopurinolum; Allorin; Allozym; Allpargin; Allural; Aloprim; Alopurinol; Aloral; Alositol; Aluline; Anoprolin; Anzief; Apulonga; Apurin; Apurol; Atisuril; Bleminol; Bloxanth; Caplenal; Capurate; Cellidrin; Cosuric; Dabrosin; Dabroson; Embarin; Epidropal; Epuric; Foligan; Geapur; Gichtex; Gotax; Hamarin; Hexanuret; Jenapurinol; Ketanrift; Ledopur; Lopurin; Lysuron; Milurit; Milurite; Miniplanor; Monarch; Nektrohan; Novopurol; Progout; Pureduct; Purinol; Remid; Riball; Rimapurinol; Roucol; Sigapurol; Suspendol; Takanarumin; Tipuric; Urbol; Uribenz; Uricemil; Uridocid; Uriprim; Uripurinol; Uritas; Urobenyl; Urolit; Urosin; Urtias; Xanthomax; Xanturat; Xanturic; Zygout; Zyloprim; Zyloric; Dura Al; Pan Quimica; A 8003; BW 56158; Urtias 100; AL-100; Allo-Puren; Allohexal (TN); Allopurinol(I); Allosig (TN); Apo-Allopurinol; BW 56-158; Ketobun-A; Progout (TN); Puricos (TN); Quimica, Pan; Zyloprim (TN); Zyloric (TN); BW-56-158; B. W. 56-158; 4-HPP Click to Show/Hide
Disease Class	5C55: Inborn purine/pyrimidine/nucleotide metabolism error
Therapeutic Class	Antimetabolites
Structure
Structure	3D Structure		2D Structure
Formula	C5H4N4O
InChI	1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
InChIKey	OFCNXPDARWKPPY-UHFFFAOYSA-N
Canonical SMILES	C1=NNC2=C1C(=O)NC=N2
External Link
	Pubchem ID	135401907
	CAS Number	315-30-0
	CHEBI ID	40279
	TTD ID	D04KYY
	INTEDE ID	DR0066
	VARIDT ID	DR00074

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM028 Competitive inhibition of renal tubular secretion BM031 Increased renal excretion (Unspecific) BM032 Decreased renal excretion (Unspecific) BM044 Additive myelosuppressive effects BM048 Increased risk of angioedema/anaphylactoid reactions BM055 Increased risk of hepatotoxicity BM079 Increased risk of skin rash BM099 Antagonize the effect of uricosuric agents
Relation Graph

Full list of drugs interacting with Allopurinol
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[21], [27], [28]
D0125		Attapulgite	Al2H29Mg2O15Si4-	56842194	Moderate		Inter Info	[21], [27], [28]
D0877		Kaolin	Al2H4O9Si2	56841936	Moderate		Inter Info	[21], [27], [28]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[21], [27], [28]
D1511		Sucralfate	C12H54Al9O55S8	121494085	Moderate		Inter Info	[21], [27], [28]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[29], [30], [31], [32], [33], [34]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[29], [30], [31], [32], [33], [34]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[32], [33], [34]
	Non-CYP450 enzyme inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0136		Azathioprine	C9H7N7O2S	2265	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D0483		Didanosine	C10H12N4O3	135398739	Major		Inter Info	[24], [25]
D1007		Mercaptopurine	C5H4N4S	667490	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[38]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[39]
	Increased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1341		Probenecid	C13H19NO4S	4911	Minor		Inter Info	[43], [9], [44]
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Minor		Inter Info	[42]
Pharmacodynamic additive effects
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[21], [22], [23]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0156		Benazepril	C24H28N2O5	5362124	Major		Inter Info	[18], [19], [20]
D0254		Captopril	C9H15NO3S	44093	Major		Inter Info	[18], [19], [20]
D0567		Enalapril	C20H28N2O5	5388962	Major		Inter Info	[18], [19], [20]
D0695		Fosinopril	C30H46NO7P	55891	Major		Inter Info	[18], [19], [20]
D0938		Lisinopril	C21H31N3O5	5362119	Major		Inter Info	[18], [19], [20]
D1082		Moexipril	C27H34N2O7	91270	Major		Inter Info	[18], [19], [20]
D1256		Perindopril	C19H32N2O5	107807	Major		Inter Info	[18], [19], [20]
D1369		Quinapril	C25H30N2O5	54892	Major		Inter Info	[18], [19], [20]
D1618		Trandolapril	C24H34N2O5	5484727	Major		Inter Info	[18], [19], [20]
D1379		Ramipril	C23H32N2O5	5362129	Major		Inter Info	[18], [19], [20]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[35], [36], [37]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[35], [36], [37]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[35], [36], [37]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[35], [36], [37]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[35], [36], [37]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[35], [36], [37]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[35], [36], [37]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[35], [36], [37]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[35], [36], [37]
	Increased risk of hepatotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1533		Tamoxifen	C26H29NO	2733526	Minor		Inter Info	[45]
	Increased risk of skin rash					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0073		Amoxicillin	C16H19N3O5S	33613	Minor		Inter Info	[20], [40], [41]
D0141		Bacampicillin	C21H27N3O7S	441397	Minor		Inter Info	[20], [40], [41]
D0079		Ampicillin	C16H19N3O4S	6249	Minor		Inter Info	[20], [40], [41]
Pharmacodynamic antagonistic effects
	Antagonize the effect of uricosuric agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1860		Pegloticase	NA	NA	Major		Inter Info	[26]

References
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25	Product Information. Videx (didanosine). Bristol-Myers Squibb, Princeton, NJ.
26	Product Information. Krystexxa (pegloticase). Savient Pharmaceuticals, East Brunswick, NJ.
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39	Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
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