Drug General Information (ID: DDILNDE2S3)
  Drug Name Allopurinol Drug Info Chlorpropamide Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antimetabolites Antidiabetic Agents
  Structure

 Mechanism of Allopurinol-Chlorpropamide Interaction (Severity Level: Minor)
     Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Allopurinol Chlorpropamide
      Mechanism Decrease the renal excretion of chlorpropamide Chlorpropamide
      Key Mechanism Factor 1
Factor Name Pharmacokinetics
Factor Description Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Decreased renal excretion of Chlorpropamide caused by Allopurinol 

References
1 Petitpierre B, Perrin L, Rudhardt M, et al "Behaviour of chlorpropamide in renal insufficiency and under the effect of associated drug therapy." Int J Clin Pharmacol 6 (1972): 120-4. [PMID: 4638970]