Details of Drug-Drug Interaction
| Drug General Information (ID: DDICYKLOD0) | |||||||||
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| Drug Name | Allopurinol | Drug Info | Fosinopril | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antimetabolites | Antihypertensive Agents | |||||||
| Structure | |||||||||
| Mechanism of Allopurinol-Fosinopril Interaction (Severity Level: Major) | |||||||||
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| Increased risk of angioedema/anaphylactoid reactions Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Allopurinol | Fosinopril | |||||||
| Mechanism | Anaphylactoid reactions | Anaphylactoid reactions | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Angioedema/anaphylactoid reactions | ||||||||
| Factor Description | Anaphylactoid reaction is a condition in which symptoms similar to an allergic reaction occur, but no immune sensitization is detected. Most commonly, the syndrome begins with skin involvement, usually pruritus, flushing, urticaria, or angioedema. Angioedema is a reaction to a trigger that causes swelling of the tissue below the inner layer of the skin, called the dermis or submucosa, and the swelling can occur on the face, throat, or around the genitals. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution is advised if allopurinol is prescribed in combination with an ACE inhibitor, particularly in the elderly and patients with renal impairment. Periodic monitoring of white blood cell counts is recommended. Patients should be advised to promptly discontinue these medications and seek medical attention if they develop dyspnea throat constriction swelling of the face, lips, or tongue urticaria rash fever arthralgia or myalgia. Patients should also contact their physician if they notice signs of infection or experience fever, chills, sore throat, lethargy, body aches, or other flu-like symptoms. | ||||||||