Drug General Information (ID: DDIG1STNXM)
Drug Name			Allopurinol		Drug Info		Magaldrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antimetabolites				Antacids
Structure

Mechanism of Allopurinol-Magaldrate Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Allopurinol				Magaldrate
Mechanism		Allopurinol				Decrease the absorption of allopurinol
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Allopurinol caused by Magaldrate

Recommended Action
Management		Allopurinol should be administered at least one hour before or two hours after aluminum-containing medications.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Weissman I, Krivoy N "Interaction of aluminum hydroxide and allopurinol in patients on chronic hemodialysis." Ann Intern Med 107 (1987): 787. [PMID: 3662305]