Details of Drug

Drug General Information (ID: D0967)
Drug Name	Magaldrate
Drug Type	Small molecule
Drug Synonymous	aluminum;magnesium;hydroxide;sulfate; AY-5710; Magaldrato; Magaldratum; Agastrin; Bemolan; Malumix; Dynese; Riopan; Riopan Plus; Magaldratum [Latin]; Magaldrato [Spanish]; Magaldrate [USAN:USP:INN:BAN]; AY 5710; Aluminum magnesium hydroxide sulfate, hydrate; Q419991; Aluminum magnesium hydroxide sulfate (Al5Mg10(OH)31(SO4)2.xH2O); Pentaaluminium-decamagnesium-hentriacontahydroxid-bis(sufat)-n-wasser Click to Show/Hide
Therapeutic Class	Antacids
Structure
Structure	3D Structure		2D Structure
Formula	AlHMgO5S+2
InChI	InChI=1S/Al.Mg.H2O4S.H2O/c;;1-5(2,3)4;/h;;(H2,1,2,3,4);1H2/q+3;+2;;/p-3
InChIKey	JIFPTBLGXRKRAO-UHFFFAOYSA-K
Canonical SMILES	[OH-].[O-]S(=O)(=O)[O-].[Mg+2].[Al+3]
External Link
External Link	Pubchem ID	3086011

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM005 Affected excretion pathways AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM003 Complex formation BM004 Adsorption BM005 Altered gastric pH BM009 Altered absorption (Unspecific) BM029 Altered urine pH BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Magaldrate
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D0356		Clobazam	C16H13ClN2O2	2789	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D0362		Clonazepam	C15H10ClN3O3	2802	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Minor		Inter Info	[168], [169], [172]
D0473		Diazepam	C16H13ClN2O	3016	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D0604		Estazolam	C16H11ClN4	3261	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D0679		Flurazepam	C21H23ClFN3O	3393	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D1060		Midazolam	C18H13ClFN3	4192	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D1197		Oxazepam	C15H11ClN2O2	4616	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D1367		Quazepam	C17H11ClF4N2S	4999	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D1547		Temazepam	C16H13ClN2O2	5391	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
D1632		Triazolam	C17H12Cl2N4	5556	Minor		Inter Info	[167], [168], [169], [170], [171], [172], [173], [174], [175]
	Complex formation					Drug Num: 55
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0515		Dolutegravir	C20H19F2N3O5	54726191	Major		Inter Info	[1]
D0181		Bictegravir	C21H18F3N3O5	90311989	Major		Inter Info	[2], [3], [4]
D1231		Patiromer	NA	NA	Major		Inter Info	[6], [7], [8]
D1377		Raltegravir	C20H21FN6O5	54671008	Major		Inter Info	[10], [2], [3], [11], [12], [13], [14]
D1605		Tolevamer	C11H16O3S	58817179	Major		Inter Info	[6], [7], [8]
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[18], [19], [20]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[28]
D0277		Cefdinir	C14H13N5O5S2	6915944	Moderate		Inter Info	[30]
D0310		Chenodeoxycholic acid	C24H40O4	10133	Moderate		Inter Info	[36]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[2], [3], [37], [38], [39], [40], [41], [42]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[46], [47], [48], [49], [50], [51], [32], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[83]
D0433		Deferiprone	C7H9NO2	2972	Moderate		Inter Info	[84]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[15], [37], [86], [87], [88], [89], [90], [91], [92], [93], [66], [94], [76]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[15], [37], [86], [87], [88], [89], [90], [91], [92], [93], [66], [94], [76]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[3], [95]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[19], [98], [20]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[99]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[58], [59], [72]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[46], [47], [48], [49], [50], [51], [32], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[2], [3], [37], [38], [39], [40], [41], [42]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[46], [47], [48], [49], [50], [51], [32], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[113], [10], [2], [3], [114], [115], [116], [117], [118], [119], [120]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[113], [10], [2], [3], [114], [115], [116], [117], [118], [119], [120]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[116], [117], [118]
D0144		Baloxavir marboxil	C27H23F2N3O7S	124081896	Moderate		Inter Info	[122]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[46], [47], [48], [49], [50], [51], [32], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
D1175		Omadacycline	C29H40N4O7	54697325	Moderate		Inter Info	[87], [90], [94]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[15], [37], [86], [87], [88], [89], [90], [91], [92], [93], [66], [94], [76]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[116], [117], [118]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[15], [37], [86], [87], [88], [89], [90], [91], [92], [93], [66], [94], [76]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[46], [47], [48], [49], [50], [51], [32], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[58], [59], [72]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[46], [47], [48], [49], [50], [51], [32], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
D1245		Penicillamine	C5H11NO2S	5852	Moderate		Inter Info	[145], [146], [147], [148], [149], [150], [151], [66]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[18], [19], [20]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[15], [37], [86], [87], [88], [89], [90], [91], [92], [93], [66], [94], [76]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[58], [59], [72]
D0010		Acebutolol	C18H28N2O4	1978	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D0117		Atenolol	C14H22N2O3	2249	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D0173		Betaxolol	C18H29NO3	2369	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D0188		Bisoprolol	C18H31NO4	2405	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D0267		Carvedilol	C24H26N2O4	2585	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D0491		Digoxin	C41H64O14	2724385	Minor		Inter Info	[197], [198], [199], [37], [200], [201], [66], [202], [203]
D0705		Gabapentin	C9H17NO2	3446	Minor		Inter Info	[205]
D0884		Labetalol	C19H24N2O3	3869	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D1049		Metoprolol	C15H25NO3	4171	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D1098		Nadolol	C17H27NO4	39147	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D1114		Nebivolol	C22H25F2NO4	71301	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Minor		Inter Info	[213]
D1293		Pindolol	C14H20N2O2	4828	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D1357		Propranolol	C16H21NO2	4946	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D1498		Sotalol	C12H20N2O3S	5253	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D1585		Timolol	C13H24N4O3S	33624	Minor		Inter Info	[37], [161], [162], [163], [164], [165], [166]
D1670		Ursodeoxycholic acid	C24H40O4	31401	Minor		Inter Info	[216]
	Adsorption					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[3]
D1350		Proguanil	C11H16ClN5	6178111	Moderate		Inter Info	[3], [139], [152]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[2]
D1366		Pyrimethamine	C12H13ClN4	4993	Moderate		Inter Info	[3], [139]
D0324		Chlorpromazine	C17H19ClN2S	2726	Minor		Inter Info	[15], [181], [182], [183], [184]
D0678		Fluphenazine	C22H26F3N3OS	3372	Minor		Inter Info	[15], [181], [182], [183], [184]
D1010		Mesoridazine	C21H26N2OS2	4078	Minor		Inter Info	[15], [181], [184]
D1257		Perphenazine	C21H26ClN3OS	4748	Minor		Inter Info	[15], [181], [182], [183], [184]
D1346		Prochlorperazine	C20H24ClN3S	4917	Minor		Inter Info	[15], [181], [182], [183], [184]
D1352		Promethazine	C17H20N2S	4927	Minor		Inter Info	[15], [181], [182], [183], [184]
D1574		Thioridazine	C21H26N2S2	5452	Minor		Inter Info	[15], [181], [182], [183], [184]
D1637		Trifluoperazine	C21H24F3N3S	5566	Minor		Inter Info	[15], [181], [182], [183], [184]
	Altered gastric pH					Drug Num: 69
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[9]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[22]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[23], [24]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[25], [26], [27]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[22]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[3], [29]
D0278		Cefditoren	C19H18N6O5S3	9870843	Moderate		Inter Info	[31]
D0288		Cefpodoxime	C15H17N5O6S2	6335986	Moderate		Inter Info	[32], [33], [34], [35]
D0297		Cefuroxime	C16H16N4O8S	5479529	Moderate		Inter Info	[32], [33], [34], [35]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[43], [44], [45]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[2], [3], [77], [78], [79], [80], [81]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[82]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[22]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[2], [3], [96], [97]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[100], [101], [102], [43], [44], [103], [45]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[100], [101], [102], [43], [44], [103], [45]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[100], [101], [102], [43], [44], [103], [45]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[104], [105], [106], [107], [108]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[104], [105], [109], [110], [3], [111], [112], [108]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[22]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[121]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[123]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[124]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[125]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[126]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[127]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[128], [22], [129]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[135], [136], [137], [138]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[135], [136], [137], [138]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[2], [3]
D1218		Pancrelipase	C8H8Na2O5	8519	Moderate		Inter Info	[2], [3], [139]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[3], [140], [141], [142], [143], [144]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[156]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[157]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[158]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[159]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[160], [27]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[43], [44], [45]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[43], [44], [45]
D0133		Axitinib	C22H18N4OS	6450551	Minor		Inter Info	[176]
D0156		Benazepril	C24H28N2O5	5362124	Minor		Inter Info	[177]
D0172		Betamethasone	C22H29FO5	9782	Minor		Inter Info	[178], [179], [180]
D0254		Captopril	C9H15NO3S	44093	Minor		Inter Info	[177]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[185], [178], [186], [187], [188], [15], [189], [190], [191], [192], [193], [194]
D0453		Dexamethasone	C22H29FO5	5743	Minor		Inter Info	[178], [179], [180]
D0539		Duloxetine	C18H19NOS	60835	Minor		Inter Info	[204]
D0567		Enalapril	C20H28N2O5	5388962	Minor		Inter Info	[177]
D0636		Famotidine	C8H15N7O2S3	5702160	Minor		Inter Info	[185], [178], [186], [187], [188], [15], [189], [190], [191], [192], [193], [194]
D0671		Fludrocortisone	C21H29FO5	31378	Minor		Inter Info	[178], [179], [180]
D0695		Fosinopril	C30H46NO7P	55891	Minor		Inter Info	[177]
D0773		Hydrocortisone	C21H30O5	5754	Minor		Inter Info	[178], [179], [180]
D0918		Levodopa	C9H11NO4	6047	Minor		Inter Info	[206], [207], [208], [209]
D0938		Lisinopril	C21H31N3O5	5362119	Minor		Inter Info	[177]
D0991		Mefenamic acid	C15H15NO2	4044	Minor		Inter Info	[210]
D1041		Methylprednisolone	C22H30O5	6741	Minor		Inter Info	[178], [179], [180]
D1082		Moexipril	C27H34N2O7	91270	Minor		Inter Info	[177]
D1109		Naproxen	C14H14O3	156391	Minor		Inter Info	[211], [212]
D1151		Nizatidine	C12H21N5O2S2	3033637	Minor		Inter Info	[185], [178], [186], [187], [188], [15], [189], [190], [191], [192], [193], [194]
D1256		Perindopril	C19H32N2O5	107807	Minor		Inter Info	[177]
D1313		Ponatinib	C29H27F3N6O	24826799	Minor		Inter Info	[2], [214]
D1332		Prednisolone	C21H28O5	5755	Minor		Inter Info	[178], [179], [180]
D1334		Prednisone	C21H26O5	5865	Minor		Inter Info	[178], [179], [180]
D1369		Quinapril	C25H30N2O5	54892	Minor		Inter Info	[177]
D1379		Ramipril	C23H32N2O5	5362129	Minor		Inter Info	[177]
D1381		Ranitidine	C13H22N4O3S	3001055	Minor		Inter Info	[185], [178], [186], [187], [188], [15], [189], [190], [191], [192], [193], [194]
D1581		Ticlopidine	C14H14ClNS	5472	Minor		Inter Info	[215]
D1618		Trandolapril	C24H34N2O5	5484727	Minor		Inter Info	[177]
D1628		Triamcinolone	C21H27FO6	31307	Minor		Inter Info	[178], [179], [180]
D1701		Vismodegib	C19H14Cl2N2O3S	24776445	Minor		Inter Info	[2], [3], [217]
	Altered absorption (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0040		Allopurinol	C5H4N4O	135401907	Moderate		Inter Info	[2], [3], [21]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[85]
D0489		Diflunisal	C13H8F2O3	3059	Minor		Inter Info	[37], [195], [196]
Affected excretion pathways
	Altered urine pH					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[15], [16], [17]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[15], [16], [17]
D1020		Methenamine	C6H12N4	4101	Moderate		Inter Info	[130], [131], [132], [133], [134]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[153], [154], [155]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[15], [16], [17]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[5]

References
1	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
5	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
6	Product Information. Resonium Calcium (calcium polystyrene sulfonate). Sanofi-Synthelabo Canada Inc, Markham, ON.
7	Ziessman HA "Alkalosis and seizure due to a cation-exchange resin and magnesium hydroxide." South Med J 69 (1976): 497-9.[PMID: 817399]
8	Madias NE, Levey AS "Metabolic alkalosis due to absorption of "nonabsorbable" antacids." Am J Med 74 (1983): 155-8.[PMID: 6849324]
9	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
10	Canadian Pharmacists Association.
11	Kiser JJ, Bumpass JB, Meditz AL, et al. "Effect of antacids on the pharmacokinetics of raltegravir in human immunodeficiency virus seronegative volunteers." Antimicrob Agents Chemother 54 (2010): 4999-5003. [PMID: 20921313]
12	Moss DM, Siccardi M, Murphy M, et al. "Divalent metals and pH alter raltegravir disposition in vitro." Antimicrob Agents Chemother 56 (2012): 3020-6. [PMID: 22450971]
13	Product Information. Isentress (raltegravir). Merck & Company Inc, West Point, PA.
14	Roberts JL, Kiser JJ, Hindman JT, Meditz AL "Virologic failure with a raltegravir-containing antiretroviral regimen and concomitant calcium administration." Pharmacotherapy 31 (2011): 298e-302e.
15	Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):.
16	Gaspari F, Vigano G, Locatelli M, Remuzzi G "Influence of antacid administrations on aspirin absorption in patients with chronic renal failure on maintenance hemodialysis." Am J Kidney Dis 11 (1988): 338-42
17	Levy G, Lampman T, Kamath BL, Garrettson LK "Decreased serum salicylate concentrations in children with rheumatic fever treated with antacid." N Engl J Med 293 (1975): 323-5
18	Product Information. Bonefos (clodronate). Rhone-Poulenc Rorer Canada Inc, Laval, QC.
19	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
20	Product Information. Skelid (tilundronate). Sanofi Winthrop Pharmaceuticals, New York, NY.
21	Weissman I, Krivoy N "Interaction of aluminum hydroxide and allopurinol in patients on chronic hemodialysis." Ann Intern Med 107 (1987): 787. [PMID: 3662305]
22	Product Information. Adderall (amphetamine-dextroamphetamine) Shire Richwood Pharmaceutical Company, Florence, KY.
23	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
24	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
25	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
26	Ray JE, Marriott D, Bloch MT, McLachlan AJ "Therapeutic drug monitoring of atazanavir: surveillance of pharmacotherapy in the clinic." Br J Clin Pharmacol 60 (2005): 291-9. [PMID: 16120068]
27	Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9. [PMID: 10930147]
28	Product Information. Zithromax (azithromycin). Pfizer US Pharmaceuticals, New York, NY.
29	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
30	Product Information. Omnicef (cefdinir). Parke-Davis, Morris Plains, NJ.
31	Product Information. Spectracef (cefditoren). TAP Pharmaceuticals Inc, Deerfield, IL.
32	Honig PK, Gillespie BK "Clinical significance of pharmacokinetic drug interactions with over-the-counter (OTC) drugs." Clin Pharmacokinet 35 (1998): 167-71. [PMID: 9784931]
33	Hughes GS, Heald DL, Barker KB, et al. "The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil." Clin Pharmacol Ther 46 (1989): 674-85. [PMID: 2557183]
34	Saathoff N, Lode H, Neider K, et al "Pharmacokinetics of cefpodoxime and interactions with an antacid and an H2 receptor antagonist." Antimicrob Agents Chemother 36 (1992): 796-800. [PMID: 1354432]
35	Sommers DK, van Wyk M, Moncrieff J, Schoeman HS "Influence of food and reduced gastric acidity on the bioavailability of bacampicillin and cefuroxime axetil." Br J Clin Pharmacol 18 (1984): 535-9. [PMID: 6091711]
36	Product Information. Chenodal (chenodeoxycholic acid). Manchester Pharmaceutical, Fort Collins, CO.
37	D'Arcy PF, McElnay JC "Drug-antacid interactions: assessment of clinical importance." Drug Intell Clin Pharm 21 (1987): 607-17. [PMID: 2886325]
38	Iwuagwu MA, Aloko KS "Adsorption of paracetamol and chloroquine phosphate by some antacids." J Pharm Pharmacol 44 (1992): 655-8. [PMID: 1359089]
39	McElnay JC, Mukhtar HA, Arcy PF, Temple DJ "In vitro experiments on chloroquine and pyrimethamine absorption in the presence of antacid constituents or kaolin." J Trop Med Hyg 85 (1982): 153-8. [PMID: 7143531]
40	McElnay JC, Mukhtar HA, D'Arcy PF, Temple DJ, Collier PS "The effect of magnesium trisilicate and kaolin on the in vivo absorption of chloroquine." J Trop Med Hyg 85 (1982): 159-63. [PMID: 6292443]
41	Product Information. Aralen (chloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.
42	Wallace AW, Amsden GW "Is it really OK to take this with food? Old interactions with a new twist." J Clin Pharmacol 42 (2002): 437-43. [PMID: 11936569]
43	Prendergast BD "Glyburide and glipizide, second-generation oral sulfonylurea hypoglycemic agents." Clin Pharm 3 (1984): 473-85. [PMID: 6435940]
44	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
45	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
46	Akerele JO, Okhamafe AO "Influence of oral co-administered metallic drugs on ofloxacin pharmacokinetics." J Antimicrob Chemother 28 (1991): 87-94. [PMID: 1663108]
47	Allen A, Vousden M, Porter A, Lewis A "Effect of Maalox((R)) on the bioavailability of oral gemifloxacin in healthy volunteers." Chemotherapy 45 (1999): 504-11. [PMID: 10567782]
48	Campbell NR, Kara M, Hasinoff BB, Haddara WM, McKay DW "Norfloxacin interaction with antacids and minerals." Br J Clin Pharmacol 33 (1992): 115-6. [PMID: 1540482]
49	Frost RW, Lasseter KC, Noe AJ, Shamblen EC, Lettieri JT "Effects of aluminum hydroxide and calcium carbonate antacids on the bioavailability of ciprofloxacin." Antimicrob Agents Chemother 36 (1992): 830-2. [PMID: 1503446]
50	Garrelts JC, Godley PJ, Peterie JD, Gerlach EH, Yakshe CC "Sucralfate significantly reduces ciprofloxacin concentrations in serum." Antimicrob Agents Chemother 34 (1990): 931-3. [PMID: 2360833]
51	Grasela TH Jr, Schentag JJ, Sedman AJ, et al "Inhibition of enoxacin absorption by antacids or ranitidine." Antimicrob Agents Chemother 33 (1989): 615-7. [PMID: 2751276]
52	Johnson RD, Dorr MB, Talbot GH, Caille G "Effect of Maalox on the oral absorption of sparfloxacin." Clin Ther 20 (1998): 1149-58. [PMID: 9916608]
53	Kamberi M, Nakashima H, Ogawa K, Oda N, Nakano S "The effect of staggered dosing of sucralfate on oral bioavailability of sparfloxacin." Br J Clin Pharmacol 49 (2000): 98-103. [PMID: 10671902]
54	Lehto P, Kivisto KT "Different effects of products containing metal ions on the absorption of lomefloxacin." Clin Pharmacol Ther 56 (1994): 477-82. [PMID: 7955811]
55	Lehto P, Kivisto KT "Effect of sucralfate on absorption of norfloxacin and ofloxacin." Antimicrob Agents Chemother 38 (1994): 248-51. [PMID: 8192452]
56	Lober S, Ziege S, Rau M, Schreiber G, Mignot A, Koeppe P, Lode H "Pharmacokinetics of gatifloxacin and interaction with an antacid containing aluminum and magnesium." Antimicrob Agents Chemother 43 (1999): 1067-71. [PMID: 10223915]
57	Nix DE, Watson WA, Lener ME, et al "Effects of aluminum and magnesium antacids and ranitidine on the absorption of ciprofloxacin." Clin Pharmacol Ther 46 (1989): 700-5. [PMID: 2598571]
58	Nix DE, Wilton JH, Ronald B, Distlerath L, Williams VC, Norman A "Inhibition of norfloxacin absorption by antacids." Antimicrob Agents Chemother 34 (1990): 432-5. [PMID: 2334155]
59	Noyes M, Polk RE "Norfloxacin and absorption of magnesium-aluminum." Ann Intern Med 109 (1988): 168-9. [PMID: 3382110]
60	Parpia SH, Nix DE, Hejmanowski LG, Goldstein HR, Wilton JH, Schentag JJ "Sucralfate reduces the gastrointestinal absorption of norfloxacin." Antimicrob Agents Chemother 33 (1989): 99-102. [PMID: 2712548]
61	Polk RE, Helay DP, Sahai J, Drwal L, Racht E "Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers." Antimicrob Agents Chemother 33 (1989): 1841-4. [PMID: 2610494]
62	Product Information. Baxdela (delafloxacin). Melinta Therapeutics, Lincolnshire, IL.
63	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
64	Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
65	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
66	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
67	Product Information. Trovan (trovafloxacin). Pfizer US Pharmaceuticals, New York, NY.
68	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
69	Sahai J, Healy DP, Stotka J, Polk RE "The influence of chronic administration of calcium carbonate on the bioavailability of oral ciprofloxacin." Br J Clin Pharmacol 35 (1993): 302-4. [PMID: 8471407]
70	Shimada J, Shiba K, Oguma T, et al "Effect of antacid on absorption of the quinolone lomefloxacin." Antimicrob Agents Chemother 36 (1992): 1219-24. [PMID: 1329615]
71	Spivey JM, Cummings DM, Pierson NR "Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction." Pharmacotherapy 16 (1996): 314-6. [PMID: 8820479]
72	Teng R, Dogolo LC, Willavize SA, Friedman HL, Vincent J "Effect of Maalox and omeprazole on the bioavailability of trovafloxacin." J Antimicrob Chemother 39 Suppl B (1997): 93-7. [PMID: 9222077]
73	Wadworth AN, Goa KL "Lomefloxacin: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use." Drugs 42 (1991): 1018-60. [PMID: 1724637]
74	Yuk JH "Ciprofloxacin levels when receiving sucralfate." J Am Geriatr Soc 262 (1989): 901. [PMID: 2754785]
75	Zix JA, Geerdes-Fenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
76	Deppermann KM, Lode H, Hoffken G, Tschink G, Kalz C, Koeppe P "Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid." Antimicrob Agents Chemother 33 (1989): 1901-7. [PMID: 2610502]
77	Product Information. Aciphex (rabeprazole) Janssen Pharmaceuticals, Titusville, NJ.
78	Product Information. Dexilant (dexlansoprazole). Takeda Pharmaceuticals America, Lincolnshire, IL.
79	Product Information. Prevacid (lansoprazole). TAP Pharmaceuticals Inc, Deerfield, IL.
80	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
81	Product Information. Zantac (ranitidine). Glaxo Wellcome, Research Triangle Park, NC.
82	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
83	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
84	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
85	Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
86	Garty M, Hurwitz A "Effect of cimetidine and antacids on gastrointestinal absorption of tetracycline." Clin Pharmacol Ther 28 (1980): 203-7. [PMID: 7398187]
87	Gotz VP, Ryerson GG "Evaluation of tetracycline on theophylline disposition in patients with chronic obstructive airways disease." Drug Intell Clin Pharm 20 (1986): 694-6. [PMID: 3757782]
88	McCormack JP, Reid SE, Lawson LM "Theophylline toxicity induced by tetracycline." Clin Pharm 9 (1990): 546-9. [PMID: 2376112]
89	Neuvonen PJ "Interactions with the absorption of tetracyclines." Drugs 11 (1976): 45-54. [PMID: 946598]
90	Nguyen VX, Nix DE, Gillikin S, Schentag JJ "Effect of oral antacid administration on the pharmacokinetics of intravenous doxycycline." Antimicrob Agents Chemother 33 (1989): 434-6. [PMID: 2729939]
91	Product Information. Declomycin (demeclocycline). Lederle Laboratories, Wayne, NJ.
92	Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
93	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
94	Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80. [PMID: 1674242]
95	Product Information. Promacta (eltrombopag). GlaxoSmithKline, Research Triangle Park, NC.
96	Duong S, Leung M "Should the concomitant use of erlotinib and acid-reducing agents be avoided? The drug interaction between erlotinib and acid-reducing agents." J Oncol Pharm Pract 17 (2011): 448-52. [PMID: 20716581]
97	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
98	Product Information. Fosamax (alendronate). Merck &amp Co, Inc, West Point, PA.
99	Product Information. Allegra (fexofenadine). Hoechst Marion-Roussel Inc, Kansas City, MO.
100	Kivisto KT, Neuvonen PJ "Effect of magnesium hydroxide on the absorption and efficacy of tolbutamide and chlorpropamide." Eur J Clin Pharmacol 42 (1992): 675-80. [PMID: 1623912]
101	Kivisto KT, Neuvonen PJ "Enhancement of absorption and effect of glipizide by magnesium hydroxide." Clin Pharmacol Ther 49 (1991): 39-43. [PMID: 1988239]
102	Kolterman OG "Glyburide in non-insulin-dependent diabetes: an update." Clin Ther 14 (1992): 196-213. [PMID: 1611644]
103	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
104	Brass C, Galgiani JN, Blaschke TF, et al "Disposition of ketoconazole, an oral antifungal, in humans." Antimicrob Agents Chemother 21 (1982): 151-8. [PMID: 6282204]
105	Carlson JA, Mann HJ, Canafax DM "Effect of pH on disintegration and dissolution of ketoconazole tablets." Am J Hosp Pharm 40 (1983): 1334-6. [PMID: 6310994]
106	Katz HI "Drug interactions of the newer oral antifungal agents." Br J Dermatol 141 (1999): 26-32. [PMID: 10730911]
107	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
108	Van der Meer JW, Keuning JJ "The influence of gastric acidity on the bio-availability of ketoconazole." J Antimicrob Chemother 6 (1980): 552-4. [PMID: 6253434]
109	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
110	Cerner Multum, Inc. "Canadian Product Information.".
111	Chin TWF, Loeb M, Fong IW "Effects of an acidic beverage (coca-cola) on absorption of ketoconazole." Antimicrob Agents Chemother 39 (1995): 1671-5. [PMID: 7486898]
112	Product Information. Ketoconazole (ketoconazole). Mylan Pharmaceuticals Inc, Morgantown, WV.
113	Campbell NR, Hasinoff BB, Stalts H, Rao B, Wong NC "Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism." Ann Intern Med 117 (1992): 1010-3. [PMID: 1443969]
114	Csako G, McGriff NJ, Rotman-Pikielny P, Sarlis NJ, Pucino F "Exaggerated levothyroxine malabsorption due to calcium carbonate supplementation in gastrointestinal disorders." Ann Pharmacother 35 (2001): 1578-83. [PMID: 11793625]
115	Liel Y, Sperber AD, Shany S "Nonspecific intestinal adsorption of levothyroxine by aluminum hydroxide." Am J Med 97 (1994): 363-5. [PMID: 7942938]
116	Neafsey PJ "Levothyroxine and calcium interaction: timing is everything." Home Healthc Nurse 22 (2004): 338-9. [PMID: 15131426]
117	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
118	Schneyer CR "Calcium carbonate and reduction of levothyroxine efficacy." JAMA 279 (1998): 750. [PMID: 9508149]
119	Singh N, Singh PN, Hershman JM "Effect of calcium carbonate on the absorption of levothyroxine." JAMA 283 (2000): 2822-5. [PMID: 10838651]
120	Sperber AD, Liel Y "Evidence for interference with the intestinal absorption of levothyroxine sodium by aluminum hydroxide." Arch Intern Med 152 (1992): 183-4. [PMID: 1728914]
121	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
122	Product Information. Xofluza (baloxavir marboxil). Genentech, South San Francisco, CA.
123	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
124	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
125	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
126	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
127	Product Information. Epclusa (sofosbuvir-velpatasvir). Gilead Sciences, Foster City, CA.
128	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
129	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
130	Kevorkian C, Merritt J, Ilstrup D "Methenamine mandelate with acidification: an effective urinary antiseptic in patients with neurogenic bladder." Mayo Clin Proc 59 (1984): 523. [PMID: 6379319]
131	Musher D, Griffith D "Generation of formaldehyde from methenamine: effect of pH and concentration, and antibacterial effect." Antimicrob Agents Chemother 6 (1974): 708-11. [PMID: 4451344]
132	Product Information. Hiprex (methenamine). Hoechst Marion-Roussel Inc, Kansas City, MO.
133	Product Information. Hyophen (benzoic acid/hyoscy/methen/mblue/phenylsal). BioComp Pharma, San Antonio, TX.
134	Sand TE, Jacobsen S "Effect of urine pH and flow on renal clearance of methotrexate." Eur J Clin Pharmacol 19 (1981): 453-6. [PMID: 7250179]
135	Bullingham R, Shah J, Goldblum R, Schiff M "Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients." Br J Clin Pharmacol 41 (1996): 513-6. [PMID: 8799515]
136	Lipsky JJ "Mycophenolate mofetil." Lancet 348 (1996): 1357-9. [PMID: 8918281]
137	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
138	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
139	Multum Information Services, Inc. Expert Review Panel.
140	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
141	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
142	Tan AR, Gibbon DG, Stein MN, et al. "Effects of ketoconazole and esomeprazole on the pharmacokinetics of pazopanib in patients with solid tumors." Cancer Chemother Pharmacol 71 (2013): 1635-43. [PMID: 23636448]
143	van Leeuwen RW, van Gelder T, Mathijssen RH, Jansman FG "Drug-drug interactions with tyrosine-kinase inhibitors: a clinical perspective." Lancet Oncol 15 (2014): e315-e326. [PMID: 24988935]
144	Yu G, Zheng QS, Wang DX, Zhou HH, Li GF "Drug interactions between tyrosine-kinase inhibitors and acid suppressive agents: more than meets the eye." Lancet Oncol 15 (2014): e469-70. [PMID: 25281461]
145	Haagsma CJ "Clinically important drug interactions with disease-modifying antirheumatic drugs." Drugs Aging 13 (1998): 281-9. [PMID: 9805209]
146	Harkness JA, Blake DR "Penicillamine nephropathy and iron." Lancet 2 (1982): 1368-9. [PMID: 6129465]
147	Joyce DA "D-penicillamine pharmacokinetics and pharmacodynamics in man." Pharmacol Ther 42 (1989): 405-27. [PMID: 2672052]
148	Lyle WH "Penicillamine and iron." Lancet 2 (1976): 420. [PMID: 73880]
149	Netter P, Bannwarth B, Pere P, Nicolas A "Clinical pharmacokinetics of D-penicillamine." Clin Pharmacokinet 13 (1987): 317-33. [PMID: 3319347]
150	Osman MA, Patel RB, Schuna A, Sundstrom WR, Welling PG "Reduction in oral penicillamine absorption by food, antacid and ferrous sulfate." Clin Pharmacol Ther 33 (1983): 465-70. [PMID: 6831825]
151	Product Information. Cuprimine (penicillamine). Merck & Co, Inc, West Point, PA.
152	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
153	Ace LN, Jaffe JM, Kunka RL "Effect of food and an antacid on quinidine bioavailability." Biopharm Drug Dispos 4 (1983): 183-90. [PMID: 6882885]
154	Romankiewicz JA, Reidenberg M, Drayer D, Franklin JE "The noninterference of aluminum hydroxide gel with quinidine sulfate absorption: An approach to control quinidine-induced diarrhea." Am Heart J 96 (1978): 518-20
155	Mauro VF, Mauro LS, Fraker TD Jr, Temesy-Armos PN, Somani P "Effect of aluminum hydroxide gel on quinidine gluconate absorption." DICP 24 (1990): 252-4
156	Product Information. Rifadin (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.
157	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
158	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
159	Product Information. Crestor (rosuvastatin). AstraZeneca Pharma Inc, Mississauga, ON.
160	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
161	McElnay JC, Temple DJ. The use of buccal partitioning as a model to examine the effects of aluminium hydroxide gel on the absorption of propranolol. Br J Clin Pharmacol. 1982;13(3):399-403. [PMID: 7059441]
162	Gugler R, Allgayer H "Effects of antacids on the clinical pharmacokinetics of drugs. An update." Clin Pharmacokinet 18 (1990): 210-9. [PMID: 1969784]
163	Hong CY, Hu SC, Lin SJ, Chiang BN "Lack of influence of aluminum hydroxide on the bioavailability and beta-adrenoceptor blocking activity of propranolol." Int J Clin Pharmacol Ther Toxicol 23 (1985): 244-6. [PMID: 4008113]
164	Kirch W, Schafer-Korting M, Axthelm T, Kohler H, Mutschler E "Interaction of atenolol with furosemide and calcium and aluminum salts." Clin Pharmacol Ther 30 (1981): 429-35. [PMID: 7285476]
165	Laer S, Neumann J, Scholz H "Interaction between sotalol and an antacid preparation." Br J Clin Pharmacol 43 (1997): 269-72. [PMID: 9088581]
166	Regardh CG, Lundborg P, Persson BA "The effect of antacid, metoclopramide, and propantheline on the bioavailability of metoprolol and atenolol." Biopharm Drug Dispos 2 (1981): 79-87. [PMID: 7236872]
167	Chun AH, Carrigan PJ, Hoffman DJ, Kershner RP, Stuart JD "Effect of antacids on absorption of clorazepate." Clin Pharmacol Ther 22 (1977): 329-35. [PMID: 19188]
168	Greenblatt DJ, Allen MD, MacLaughlin DS, Harmatz JS, Shader RI "Diazepam absorption: effect of antacids and food." Clin Pharmacol Ther 24 (1978): 600-9. [PMID: 699484]
169	Greenblatt DJ, Shader RI, Harmatz JS, Franke K, Koch-Weser J "Absorption rate, blood concentrations, and early response to oral chlordiazepoxide." Am J Psychiatry 134 (1977): 559-62. [PMID: 848586]
170	Greenblatt DJ, Shader RI, Harmatz JS, Franke K, Koch-Weser J "Influence of magnesium and aluminum hydroxide mixture on chlordiazepoxide absorption." Clin Pharmacol Ther 19 (1976): 234-9. [PMID: 770046]
171	Kroboth PD, Smith RB, Rault R, Silver MR, Sorkin MI, Puschett JB, Juhl RP "Effects of end-stage renal disease and aluminum hydroxide on temazepam kinetics." Clin Pharmacol Ther 37 (1985): 453-9. [PMID: 2858279]
172	Kroboth PD, Smith RB, Silver MR, Rault R, Sorkin MI, Puschett JB, Juhl RP "Effects of end stage renal disease and aluminium hydroxide on triazolam pharmacokinetics." Br J Clin Pharmacol 19 (1985): 839-42. [PMID: 2862896]
173	Nair SG, Gamble JA, Dundee JW, Howard PJ "The influence of three antacids on the absorption and clinical action of oral diazepam." Br J Anaesth 48 (1976): 1175-80. [PMID: 1023953]
174	Shader RI, Ciraulo DA, Greenblatt DJ, Harmatz JS "Steady-state plasma desmethyldiazepam during long-term clorazepate use: effects of antacids." Clin Pharmacol Ther 31 (1982): 180-3. [PMID: 6120059]
175	Shader RI, Georgotas A, Greenblatt DJ, Harmatz JS, Allen MD "Impaired absorption of desmethyldiazepam from clorazepate by magnesium aluminum hydroxide." Clin Pharmacol Ther 24 (1978): 308-15. [PMID: 28870]
176	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
177	Mantyla R, Mannisto PT, Vuorela A, Sundberg S, Ottoila P "Impairment of captopril bioavailability by concomitant food and antacid intake." Int J Clin Pharmacol Ther Toxicol 22 (1984): 626-9. [PMID: 6389377]
178	Albin H, Vincon G, Demotes-Mainard F, et al "Effect of aluminium phosphate on the bioavailability of cimetidine and prednisolone." Eur J Clin Pharmacol 26 (1984): 271-3. [PMID: 6723769]
179	Naggar VF, Khalil SA, Gouda MW "Effect of concomitant administration of magnesium trisilicate on GI absorption of dexamethasone in humans." J Pharm Sci 67 (1978): 1029-30. [PMID: 207854]
180	Tanner AR, Caffin JA, Halliday JW, Powell LW "Concurrent administration of antacids and prednisone: effect on serum levels of prednisolone." Br J Clin Pharmacol 7 (1979): 397-400. [PMID: 444359]
181	Fann WE "Interactions of psychotropic drugs in the elderly." Postgrad Med 53 (1973): 182-6. [PMID: 4144160]
182	Fann WE, Davis JM, Janowsky DS, Sekerke HJ, Schmidt DM "Chlorpromazine: effects of antacids on its gastrointestinal absorption." J Clin Pharmacol 13 (1973): 388-90. [PMID: 4355737]
183	Forrest FM, Forrest IS, Serra MT "Modification of chlorpromazine metabolism by some other drugs frequently administered to psychiatric patients." Biol Psychiatry 2 (1970): 53-8. [PMID: 5414905]
184	Romankiewicz JA "Effects of antacids on gastrointestinal absorption of drugs." Prim Care 3 (1976): 537-50. [PMID: 61596]
185	Albin H, Vincon G, Begaud B, Bistue C, Perez P "Effect of aluminum phosphate on the bioavailability of ranitidine." Eur J Clin Pharmacol 32 (1987): 97-9. [PMID: 3582475]
186	Bachmann KA, Sullivan TJ, Jauregui L, Reese J, Miller K, Levine L "Drug interactions of h-2-receptor antagonists." Scand J Gastroenterol 29 (1994): 14-9. [PMID: 7863246]
187	Barzaghi N, Gatti G, Crema F, Perucca E "Impaired bioavailability of famotidine given concurrently with a potent antacid." J Clin Pharmacol 29 (1989): 670-2. [PMID: 2569486]
188	Bodemar G, Norlander B, Walan A "Diminished absorption of cimetidine caused by antacids." Lancet 02/24/79 (1979): 444-5. [PMID: 84296]
189	Donn KH, Eshelman FN, Plachetka JR, et al "The effects of antacid and propantheline on the absorption of oral ranitidine." Pharmacotherapy 4 (1984): 89-92. [PMID: 6326064]
190	Lin JH, Chremos AN, Kanovsky SM, Schwartz S, Yeh KC, Kann J "Effects of antacids and food on absorption of famotidine." Br J Clin Pharmacol 24 (1987): 551-3. [PMID: 2891370]
191	Mihaly GW, Marino AT, Webster LK, Jones DB, Louis WJ, Smallwood RA "High dose of antacid (Mylanta II) reduces bioavailability of ranitidine." Br Med J 285 (1982): 998-9. [PMID: 6289961]
192	Russell WL, Lopez LM, Normann SA, et al "Effect of antacids on predicted steady-state cimetidine concentrations." Dig Dis Sci 29 (1984): 385-9. [PMID: 6714054]
193	Shelly DW, Doering PL, Russell WL, Guild RT, Lopez LM, Perrin J "Effect of concomitant antacid administration on plasma cimetidine concentrations during repetitive dosing." Drug Intell Clin Pharm 20 (1986): 792-5. [PMID: 3769772]
194	Steinberg WM, Lewis JH, Katz DM "Antacids inhibit absorption of cimetidine." N Engl J Med 307 (1982): 400-4. [PMID: 7088113]
195	Product Information. Dolobid (diflunisal). Merck & Co, Inc, West Point, PA.
196	Verbeeck R, Tjandramaga TB, Mullie A, Verbesselt R, de Schepper PJ "Effect of aluminum hydroxide on diflunisal absorption." Br J Clin Pharmacol 7 (1979): 519-22. [PMID: 314299]
197	Allen MD, Greenblatt DJ, Harmatz JS, Smith TW "Effect of magnesium--aluminum hydroxide and kaolin--pectin on absorption of digoxin from tablets and capsules." J Clin Pharmacol 21 (1981): 26-30. [PMID: 7012189]
198	Bonelli J, Hruby K, Magometschnigg D, Hitzenberger G, Kaik G "The bio-availability of beta-acetyldigoxine alone and combined with aluminum hydroxide and magnesium hydroxide (Alucol)." Int J Clin Pharmacol Biopharm 15 (1977): 337-9. [PMID: 892951]
199	Brown DD, Juhl RP "Decreased bioavailability of digoxin due to antacids and kaolin-pectin." N Engl J Med 295 (1976): 1034-7. [PMID: 972657]
200	Marcus FI "Pharmacokinetic interactions between digoxin and other drugs." J Am Coll Cardiol 5 (1985): a82-90. [PMID: 2985676]
201	McElnay JC, Harron DW, D'Arcy PF, Eagle MR "Interaction of digoxin with antacid constituents." Br Med J 1 (1978): 1554. [PMID: 656806]
202	Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44. [PMID: 3056649]
203	Liu F, Qiu M, Zhai SD. Tolerability and effectiveness of (S)-amlodipine compared with racemic amlodipine in hypertension: a systematic review and meta-analysis.?Curr Ther Res Clin Exp. 2010;71(1):1-29. [PMID: 24683248]
204	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
205	Product Information. Neurontin (gabapentin). Parke-Davis, Morris Plains, NJ.
206	Fermaglich J, O'Dougherty DS "Effect of gastric motility on levodopa." Dis Nerv Syst 33 (1972): 624-5. [PMID: 4649158]
207	Product Information. Sinemet (carbidopa-levodopa). DuPont Pharmaceuticals, Wilmington, DE.
208	Rivera-Calimlim L, Dujovne CA, Morgan JP, Lasagna L, Bianchine JR "Absorption and metabolism of L-dopa by the human stomach." Eur J Clin Invest 1 (1971): 313-20. [PMID: 5558777]
209	Rivera-Calimlin L, Dujovne CA, Morgan JP, Lasagna L, Bianchine JR "L-dopa treatment failure: explanation and correction." Br Med J 4 (1970): 93-4. [PMID: 5482325]
210	Neuvonen PJ, Kivisto KT "Effect of magnesium hydroxide on the absorption of tolfenamic and mefenamic acids." Eur J Clin Pharmacol 35 (1988): 495-501. [PMID: 3266151]
211	Brogden RN, Heel RC, Speight TM, Avery GS "Naproxen up to date: a review of its pharmacological properties and therapeutic efficacy and use in rheumatic diseases and pain states." Drugs 18 (1979): 241-77. [PMID: 387372]
212	Segre EJ, Sevelius H, Varady J "Effects of antacids on naproxen absorption." N Engl J Med 291 (1974): 582-3. [PMID: 4852768]
213	Naggar VF, Khalil SA "Effect of magnesium trisilicate on nitrofurantoin absorption." Clin Pharmacol Ther 25 (1979): 857-63. [PMID: 36251]
214	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
215	Product Information. Ticlid (ticlopidine). Syntex Laboratories Inc, Palo Alto, CA.
216	Product Information. Actigall capsules (ursodiol). Novartis Pharmaceutical, Research Triangle Pk, NC.
217	Product Information. Erivedge (vismodegib). Genentech, South San Francisco, CA.

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