Drug General Information (ID: DDIVXUZH95)
Drug Name			Chenodeoxycholic acid		Drug Info		Magaldrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gallstone Solubilizing Agents				Antacids
Structure

Mechanism of Chenodeoxycholic acid-Magaldrate Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Chenodeoxycholic acid				Magaldrate
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Magaldrate due to formation of complexes caused by Chenodeoxycholic acid

Recommended Action
Management		To minimize the potential for interaction, it may be helpful to separate the dosing of chenodeoxycholic acid and aluminum-based antacids by several hours. However, clinical data are lacking to support a recommendation.

References
1	Product Information. Chenodal (chenodeoxycholic acid). Manchester Pharmaceutical, Fort Collins, CO.