Details of Drug

Details of Drug

 Drug General Information (ID: D0310)
  Drug Name
Chenodeoxycholic acid
  Drug Type Small molecule
  Drug Synonymous
474-25-9; Chenix; Chenic acid; Chenodeoxycholate; Gallodesoxycholic acid; Chendol; Chenodesoxycholic acid; Cdca; Chenofalk; Anthropodeoxycholic acid; Anthropodesoxycholic acid; Anthropododesoxycholic acid; Chenodesoxycholsaeure; Xenbilox; Henohol; Chenique Acid; Chenodiol [USAN]; 3alpha,7alpha-Dihydroxy-5beta-cholan-24-oic acid; Sodium chenodeoxycholate; Acido chenodeoxicholico; Chenodesoxycholsaeure [German]; Acide chenodeoxycholique; 7-alpha-Hydroxylithocholic acid; Acidum chenodeoxycholicum
    Click to Show/Hide
  Disease Class DC11: Cholelithiasis
  Therapeutic Class Gallstone Solubilizing Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C24H40O4
  InChI 1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1
  InChIKey RUDATBOHQWOJDD-BSWAIDMHSA-N
  Canonical SMILES CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
  External Link
Pubchem ID 10133
CAS Number 474-25-9
CHEBI ID 16755
TTD ID D03ZTE
INTEDE ID DR0295
VARIDT ID DR00524

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM006  Pharmacodynamic additive effects
BM003  Complex formation
BM050  Increased risk of bleeding
BM055  Increased risk of hepatotoxicity
  Relation Graph
 Full list of drugs interacting with Chenodeoxycholic acid
      Affected gastrointestinal absorption
   Complex formation Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0967
 
Magaldrate
 
AlHMgO5S+2
 
3086011 
Moderate    Inter Info   
[7]
D0329
 
Cholestyramine
 
C27H47ClN2
 
137699107 
Moderate    Inter Info   
[7], [32], [33]
D0381
 
Colesevelam
 
C31H67Cl3N4O
 
160051 
Moderate    Inter Info   
[7], [32], [33]
D0382
 
Colestipol
 
C11H28ClN5O
 
62816 
Moderate    Inter Info   
[7], [32], [33]
D0877
 
Kaolin
 
Al2H4O9Si2
 
56841936 
Moderate    Inter Info   
[7]
D1511
 
Sucralfate
 
C12H54Al9O55S8
 
121494085 
Moderate    Inter Info   
[7]
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[7]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[35], [36], [7]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[7]
   Increased risk of hepatotoxicity Drug Num:  23
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0944
 
Lomitapide
 
C39H37F6N3O2
 
9853053 
Major    Inter Info   
[1]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Major    Inter Info   
[2]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Major    Inter Info   
[3], [4], [5]
D0900
 
Leflunomide
 
C12H9F3N2O2
 
3899 
Major    Inter Info   
[3], [4], [5]
D1073
 
Mipomersen
 
C230H324N67O122P19S19
 
118984467 
Major    Inter Info   
[6]
D0114
 
Asparaginase Escherichia coli
 
NA
 
NA
Moderate    Inter Info   
[8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0113
 
Asparaginase Erwinia chrysanthemi
 
NA
 
NA
Moderate    Inter Info   
[8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0149
 
Bedaquiline
 
C32H31BrN2O2
 
5388906 
Moderate    Inter Info   
[21]
D0199
 
Brentuximab vedotin
 
NA
 
NA
Moderate    Inter Info   
[22]
D0248
 
Cannabidiol
 
C21H30O2
 
644019 
Moderate    Inter Info   
[12], [23]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[24]
D1239
 
Peginterferon beta-1a
 
NA
 
NA
Moderate    Inter Info   
[25], [26], [27], [28]
D1389
 
Remdesivir
 
C27H35N6O8P
 
121304016 
Moderate    Inter Info   
[11], [12], [29], [30], [31]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Moderate    Inter Info   
[34]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[37], [38]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Moderate    Inter Info   
[11], [12], [39]
D0826
 
Interferon beta-1a
 
NA
 
NA
Moderate    Inter Info   
[25], [26], [27], [28]
D0827
 
Interferon beta-1b
 
NA
 
NA
Moderate    Inter Info   
[25], [26], [27], [28]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[12], [40]
D1106
 
Naltrexone
 
C20H23NO4
 
5360515 
Moderate    Inter Info   
[41]
D1234
 
Pegaspargase
 
C14H19NO
 
436058 
Moderate    Inter Info   
[8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1589
 
Tioguanine
 
C5H5N5S
 
2723601 
Moderate    Inter Info   
[42], [43]
D1615
 
Trabectedin
 
C39H43N3O11S
 
108150 
Moderate    Inter Info   
[12], [44]
References
1 Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
2 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
3 Canadian Pharmacists Association.
4 EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
5 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
6 Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
7 Product Information. Chenodal (chenodeoxycholic acid). Manchester Pharmaceutical, Fort Collins, CO.
8 Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
9 Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
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12 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
13 Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
14 Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
15 Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
16 Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
17 Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
18 Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
19 Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
20 Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
21 Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
22 Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
23 Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
24 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
25 Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
26 Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
27 Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
28 Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
29 European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
30 Gilead Sciences, Inc "About Remdesivir.".
31 US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
32 Product Information. Questran (cholestyramine). Par Pharmaceutical Inc, Chestnut Ridge, NY.
33 Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
34 Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
35 Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
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37 Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
38 Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
39 Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
40 Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
41 Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
42 Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
43 Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
44 Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.