Drug General Information (ID: DDILJBQOFW)
Drug Name			Sucralfate		Drug Info		Chenodeoxycholic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Gallstone Solubilizing Agents
Structure

Mechanism of Sucralfate-Chenodeoxycholic acid Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Chenodeoxycholic acid
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Chenodeoxycholic acid

Recommended Action
Management		To minimize the potential for interaction, it may be helpful to separate the dosing of chenodeoxycholic acid and aluminum-based antacids by several hours. However, clinical data are lacking to support a recommendation.

References
1	Product Information. Chenodal (chenodeoxycholic acid). Manchester Pharmaceutical, Fort Collins, CO.