Details of Drug-Drug Interaction
| Drug General Information (ID: DDIWY5LOTE) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Allopurinol | Drug Info | Tamoxifen | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antimetabolites | Antineoplastics | |||||||
| Structure | |||||||||
| Mechanism of Allopurinol-Tamoxifen Interaction (Severity Level: Minor) | |||||||||
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| Increased risk of hepatotoxicity Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Allopurinol | Tamoxifen | |||||||
| Mechanism | Hepatotoxicity | Hepatotoxicity | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Hepatotoxicity | ||||||||
| Factor Description | Combination of drugs that can induce hepatotoxicity may increase the risk of liver injury. Symptoms vary depending on the level of exposure and the total extent of liver damage, and may cause few symptoms if the damage is mild, and eventually lead to liver failure in patients with severe damage. | ||||||||
| Mechanism Description |
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| References | |||||||||||||||||||
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| 1 | Shah KA, Levin J, Rosen N, Greenwald E, Zumoff B "Allopurinol hepatotoxicity potentiated by tamoxifen." N Y State J Med 82 (1982): 1745-6. [PMID: 6960280] | ||||||||||||||||||