Drug General Information (ID: DDI0EG5SIF)
Drug Name			Allopurinol		Drug Info		Bacampicillin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antimetabolites				Antibiotics
Structure

Mechanism of Allopurinol-Bacampicillin Interaction (Severity Level: Minor)
Increased risk of skin rash Click to Show/Hide Mechanism Graph
Drug Name		Allopurinol				Bacampicillin
Mechanism		Skin rash				Skin rash
Key Mechanism Factor 1
		Factor Name		Skin rash
		Factor Description		Skin rashes are the body's reaction to a certain drug. The type of rash that occurs depends on the drug that causes the rash and your reaction to it. Medications are associated with every type of rash, from mild to life-threatening. The timing of the rash may also vary.
Mechanism Description		Increased risk of skin rash by the combination of Allopurinol and Bacampicillin

References
1	Product Information. Zyloprim capsules (allopurinol). Glaxo Wellcome, Research Triangle Park, NC.
2	Jick H, Porter JB "Potentiation of ampicillin skin reactions by allopurinol or hyperuricemia." J Clin Pharmacol 21 (1981): 456-8
3	Boston Collaborative Drug Surveillance Program "Excess of ampicillin rashes associated with allopurinol or hyperuricemia." N Engl J Med 286 (1972): 505-7