Drug General Information (ID: DDIEPVR9TF)
Drug Name			Sucralfate		Drug Info		Allopurinol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Antimetabolites
Structure

Mechanism of Sucralfate-Allopurinol Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Allopurinol
Mechanism		Aluminum-containing products				Absorption decreased by aluminum-containing products
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Allopurinol caused by Sucralfate

Recommended Action
Management		Allopurinol should be administered at least one hour before or two hours after aluminum-containing medications.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Weissman I, Krivoy N "Interaction of aluminum hydroxide and allopurinol in patients on chronic hemodialysis." Ann Intern Med 107 (1987): 787. [PMID: 3662305]