Details of Drug

Drug General Information (ID: D1570)
Drug Name	Theophylline
Drug Type	Small molecule
Drug Synonymous	Bronchoretard; Cetraphylline; Chronophyllin; Dimethylxanthine; Elixophylline; Liquophylline; Pseudotheophylline; Afonilum Retard; Bronchodid Duracap; Elixophyllin SR; Somophyllin CRT; Spophyllin retard; Telbans DrySyrup; Teofilina [Polish]; Theal tablets; Theobid Duracap; Theodur Dry Syrup; Uniphyllin continus; Elixophyllin (TN); Elixophyllin(e); Pulmo-Timelets; Somophyllin-CRT; Somophyllin-DF; Theo-Organidin; Theoclear-200; Theodur G (TN); Theolair (TN); Theophylline (JP15); Theophylline-SR; Quibron-t (TN); Theo-Dur-Sprinkle; Theophylline-[8-3H; Theoclear L.A.-130; 1,3 Dimethylxanthine; 1,3-Dimethylxanthine; 1H-purine-2,6-dione Click to Show/Hide
Disease Class	CA22: Chronic obstructive pulmonary disease
Therapeutic Class	Bronchodilators
Structure
Structure	3D Structure		2D Structure
Formula	C7H8N4O2
InChI	1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
InChIKey	ZFXYFBGIUFBOJW-UHFFFAOYSA-N
Canonical SMILES	CN1C2=C(C(=O)N(C1=O)C)NC=N2
External Link
	Pubchem ID	2153
	CAS Number	58-55-9
	CHEBI ID	28177
	TTD ID	D0DF2M
	INTEDE ID	DR1575
	VARIDT ID	DR00191

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM004 Adsorption BM009 Altered absorption (Unspecific) BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM026 Increased metabolism (Unspecific) BM032 Decreased renal excretion (Unspecific) BM042 Additive hypotensive effects BM065 Increased risk of hypokalemia BM069 Increased risk of lowers seizure threshold BM087 Antagonize the effect of antiepileptic agents BM090 Antagonize the effect of bronchodilators BM095 Antagonize the effect of neuromuscular blocking agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Theophylline
Affected gastrointestinal absorption
	Complex formation					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[18], [239]
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
	Altered absorption (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0640		Felodipine	C18H19Cl2NO4	3333	Minor		Inter Info	[318], [3]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[319], [320]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Minor		Inter Info	[321]
D1095		Mycophenolic acid	C17H20O6	446541	Minor		Inter Info	[321]
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1906		Thallous Chloride	ClTl	24642	Moderate		Inter Info	[89], [299], [300]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[96], [98], [103]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[5], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106]
	CYP450 enzyme inhibition					Drug Num: 63
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[60]
D0573		Enoxacin	C15H17FN4O3	3229	Major		Inter Info	[61], [7], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [56], [57], [72], [58], [59], [73]
D1054		Mexiletine	C11H17NO	4178	Major		Inter Info	[81], [82], [83], [84], [85], [86], [87], [88], [3]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[89], [5], [107]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [49], [134], [56], [135], [136], [137]
D0231		Caffeine	C8H10N4O2	2519	Moderate		Inter Info	[141], [142]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[143], [144], [56]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [49], [134], [56], [135], [136], [137]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[145], [146], [147]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[89], [5], [145], [148], [149], [146], [147], [3], [150]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[89], [5], [145], [148], [149], [146], [147], [3], [150]
D0825		Interferon alfa-n3	NA	NA	Moderate		Inter Info	[89], [5], [145], [148], [149], [146], [147], [3], [150]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[89], [5], [145], [148], [149], [146], [147], [3], [150]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[89], [5], [145], [148], [149], [146], [147], [3], [150]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[89], [5], [145], [148], [149], [146], [147], [3], [150]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[89], [5], [145], [148], [149], [146], [147], [3], [150]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[154]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[89], [5], [145], [148], [149], [146], [147], [3], [150]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[89], [5], [145], [148], [149], [146], [147], [3], [150]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[162]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[192]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[196]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[199]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[89], [5], [202]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[203], [204], [205], [206], [207], [208], [209], [210], [7], [211], [212], [213], [214], [215], [216], [217], [218], [42], [219], [220], [221], [222], [223], [224], [225], [3], [226], [227], [228]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[229], [230], [231], [232], [39], [233], [234], [235], [236], [237], [46], [238], [51], [56], [58], [59]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [49], [134], [56], [135], [136], [137]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[143], [144], [56]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[240], [241], [242], [219], [243], [244], [3]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[246], [3]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[203], [204], [205], [206], [207], [208], [209], [210], [7], [211], [212], [213], [214], [215], [216], [217], [218], [42], [219], [220], [221], [222], [223], [224], [225], [3], [226], [227], [228]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[89], [5], [251]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[252]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[261]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[262], [263]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[264], [265], [266], [56]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[89], [5], [267]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[268], [269], [270]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[278]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[143], [144], [56]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[229], [230], [231], [232], [39], [233], [234], [235], [236], [237], [46], [238], [51], [56], [58], [59]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[279]
D1151		Nizatidine	C12H21N5O2S2	3033637	Moderate		Inter Info	[203], [204], [205], [206], [207], [208], [209], [210], [7], [211], [212], [213], [214], [215], [216], [217], [218], [42], [219], [220], [221], [222], [223], [224], [225], [3], [226], [227], [228]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[229], [230], [231], [232], [39], [233], [234], [235], [236], [237], [46], [238], [51], [56], [58], [59]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[280]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[229], [230], [231], [232], [39], [233], [234], [235], [236], [237], [46], [238], [51], [56], [58], [59]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[281]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[143], [144], [56]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[89], [5], [145], [148], [149], [146], [147], [3], [150]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[203], [204], [205], [206], [207], [208], [209], [210], [7], [211], [212], [213], [214], [215], [216], [217], [218], [42], [219], [220], [221], [222], [223], [224], [225], [3], [226], [227], [228]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[203], [213], [224]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[289]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[202]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[296]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[143], [144], [56]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [49], [134], [56], [135], [136], [137]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[304]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[240], [305], [306], [307], [308], [309], [310], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[89], [5], [311]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[312], [313], [314]
D1405		Riluzole	C8H5F3N2OS	5070	Minor		Inter Info	[323]
	Non-CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0637		Febuxostat	C16H16N2O3S	134018	Moderate		Inter Info	[250]
	CYP450 enzyme induction					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[138], [139], [140], [56]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[138], [139], [140], [56]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[155], [156], [157], [56]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[89], [5], [158]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[191]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[138], [139], [140], [56]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[89], [5], [197], [198]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[200], [201], [56]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[155], [156], [157], [56]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[155], [156], [157], [56]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[155], [156], [157], [56]
D1024		Methohexital	C14H18N2O3	9034	Moderate		Inter Info	[138], [139], [140], [56]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[138], [139], [56]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[89], [5], [202]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[282]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[138], [139], [140], [56]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[138], [139], [140], [56]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[138], [139], [140], [56]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[264], [285], [286]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[287], [288]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[138], [139], [140], [56]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[89], [5], [158]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[89], [5], [292], [158]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[293], [294], [295]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[89], [5], [298]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[138], [139], [140], [56]
	Competitive inhibition of metabolic enzyme					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[245], [18], [89], [5]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[290], [291]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[297]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[290], [291]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[290], [291]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[5], [324]
	Decreased metabolism (Unspecific)					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[247], [248], [249]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[247], [248], [249]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[247], [248], [249]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[247], [248], [249]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[247], [248], [249]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[247], [248], [249]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[247], [248], [249]
D1571		Thiabendazole	C10H7N3S	5430	Moderate		Inter Info	[301], [302], [303], [3]
	Increased metabolism (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[271], [272], [273]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[271], [272], [273]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[271], [272], [273]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[271], [272], [273]
Affected excretion pathways
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[277]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1408		Riociguat	C20H19FN8O2	11304743	Major		Inter Info	[89], [5], [90]
	Increased risk of hypokalemia					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[151], [152], [153]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[151], [152], [153]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[193], [194], [195]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[193], [194], [195]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[193], [194], [195]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[193], [194], [195]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[193], [194], [195]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[151], [152], [153]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[193], [194], [195]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[151], [152], [153]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[151], [152], [153]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[151], [152], [153]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[193], [194], [195]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[151], [152], [153]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[151], [152], [153]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[151], [152], [153]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[193], [194], [195]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[193], [194], [195]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[151], [152], [153]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[151], [152], [153]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[151], [152], [153]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[151], [152], [153]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[193], [194], [195]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[193], [194], [195]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[151], [152], [153]
	Increased risk of lowers seizure threshold					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[76], [77], [78], [79], [80]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[76], [77], [78], [79], [80]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[91], [29], [28], [92]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[89], [5]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[253], [254], [255], [256], [257], [258], [259], [260]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[274], [275], [276]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[283], [284], [5]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[283], [284], [5]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[283], [284], [5]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[74], [75]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0951		Lorazepam	C15H10Cl2N2O2	3958	Minor		Inter Info	[315], [316], [317]
D1547		Temazepam	C16H13ClN2O2	5391	Minor		Inter Info	[315], [316], [317]
D0045		Alprazolam	C17H13ClN4	2118	Minor		Inter Info	[315], [316], [317]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Minor		Inter Info	[315], [316], [317]
D0356		Clobazam	C16H13ClN2O2	2789	Minor		Inter Info	[315], [316], [317]
D0362		Clonazepam	C15H10ClN3O3	2802	Minor		Inter Info	[315], [316], [317]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Minor		Inter Info	[315], [316], [317]
D0473		Diazepam	C16H13ClN2O	3016	Minor		Inter Info	[315], [316], [317]
D0604		Estazolam	C16H11ClN4	3261	Minor		Inter Info	[315], [316], [317]
D0679		Flurazepam	C21H23ClFN3O	3393	Minor		Inter Info	[315], [316], [317]
D0748		Halazepam	C17H12ClF3N2O	31640	Minor		Inter Info	[315], [316], [317]
D1060		Midazolam	C18H13ClFN3	4192	Minor		Inter Info	[315], [316], [317]
D1197		Oxazepam	C15H11ClN2O2	4616	Minor		Inter Info	[315], [316], [317]
D1367		Quazepam	C17H11ClF4N2S	4999	Minor		Inter Info	[315], [316], [317]
D1391		Remimazolam	C21H19BrN4O2	9867812	Minor		Inter Info	[315], [316], [317]
D1632		Triazolam	C17H12Cl2N4	5556	Minor		Inter Info	[315], [316], [317]
	Antagonize the effect of bronchodilators					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0173		Betaxolol	C18H29NO3	2369	Major		Inter Info	[1], [2], [3]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Major		Inter Info	[1], [2], [3]
D0602		Esmolol	C16H25NO4	59768	Major		Inter Info	[1], [2], [3]
D1049		Metoprolol	C15H25NO3	4171	Major		Inter Info	[1], [2], [3]
D0010		Acebutolol	C18H28N2O4	1978	Major		Inter Info	[1], [2], [3]
D0117		Atenolol	C14H22N2O3	2249	Major		Inter Info	[1], [2], [3]
D0188		Bisoprolol	C18H31NO4	2405	Major		Inter Info	[1], [2], [3]
D0265		Carteolol	C16H24N2O3	2583	Major		Inter Info	[1], [2], [3]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Major		Inter Info	[1], [2], [3]
D0267		Carvedilol	C24H26N2O4	2585	Major		Inter Info	[1], [2], [3]
D0884		Labetalol	C19H24N2O3	3869	Major		Inter Info	[1], [2], [3]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Major		Inter Info	[1], [2], [3]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Major		Inter Info	[1], [2], [3]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Major		Inter Info	[1], [2], [3]
D1098		Nadolol	C17H27NO4	39147	Major		Inter Info	[1], [2], [3]
D1114		Nebivolol	C22H25F2NO4	71301	Major		Inter Info	[1], [2], [3]
D1244		Penbutolol	C18H29NO2	37464	Major		Inter Info	[1], [2], [3]
D1293		Pindolol	C14H20N2O2	4828	Major		Inter Info	[1], [2], [3]
D1357		Propranolol	C16H21NO2	4946	Major		Inter Info	[1], [2], [3]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3]
D1585		Timolol	C13H24N4O3S	33624	Major		Inter Info	[1], [2], [3]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Major		Inter Info	[1], [2], [3]
	Antagonize the effect of neuromuscular blocking agents					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[159], [160], [161]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[159], [160], [161]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[159], [160], [161]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[159], [160], [161]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[159], [160], [161]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[159], [160], [161]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[159], [160], [161]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[159], [160], [161]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[159], [160], [161]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[159], [160], [161]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[159], [160], [161]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[188], [189], [190]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[188], [189], [190]
D1877		Regadenoson	C15H18N8O5	219024	Moderate		Inter Info	[188], [189], [190]
D1356		Propofol	C12H18O	4943	Minor		Inter Info	[141], [142], [322]

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103	Product Information. Skyrizi (risankizumab). AbbVie US LLC, North Chicago, IL.
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