Drug General Information (ID: DDIA3E2XNK)
  Drug Name Theophylline Drug Info Ketoconazole Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Bronchodilators Antifungal Agents
  Structure

 Mechanism of Theophylline-Ketoconazole Interaction (Severity Level: Minor)
     Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Theophylline Ketoconazole
      Mechanism Theophylline Decrease the absorption of theophylline
      Key Mechanism Factor 1
Factor Name Pharmacokinetic
Factor Description Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Altered absorption of Theophylline caused by Ketoconazole 

References
1 Brown MW, Maldonado AL, Meredith CG, Speeg KV "Effect of ketoconazole on hepatic oxidative drug metabolism." Clin Pharmacol Ther 37 (1985): 290-7. [PMID: 3971653]
2 Heusner JJ, Dukes GE, Rollins DE, et al "Effect of chronically administered ketoconazole on the elimination of theophylline in man." Drug Intell Clin Pharm 21 (1987): 514-7. [PMID: 3608798]